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Blood, Vol. 101, Issue 4, 1645-1652, February 15, 2003
Supplemental materials for: Luznik et al, Vol 101, Issue 4, 1645-1652. Supplemental Figure:
Figure S1. Allogeneic T cells, sensitized against host antigens, retard the growth of breast cancer metastases but fail to control the growth of primary tumor (JPEG, 57 KB): (a) Experimental scheme. (b,c) BALB/c mice (N = 5-10 per group) received 850 cGy TBI on day –28 and 1 x 107 DBA/2 BM cells IV on day -27. On day –7, animals that had received transplants were infused with spleen cells from unprimed DBA/2 mice (○) or from DBA/2 donors primed against BALB/c cells 2 weeks earlier (▼). On day 0 all mice that had received transplants, and a group of 5 naive BALB/c controls (●), were challenged with 104 4T1 breast cancer cells subcutaneously. (b) Survival after tumor inoculation. (c) Mean diameter of primary tumor following inoculation. †P < .05, compared with animals receiving transplants. *P < .001, compared with animals receiving transplants (Anova test). (d,e) Hematoxylin and eosin stained sections (40x) of lung tissue taken 4 weeks after tumor challenge in chimeric mouse recipients of unprimed (d) or primed (e) DBA/2 splenocytes. Arrows point to metastases of 4T1.
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| Copyright © 2009 by American Society of Hematology Online ISSN: 1528-0020 | |||||||||
