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 Blood, 15 November 2003, Vol. 102, No. 10, pp. 3848.

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CORRESPONDENCE

To the editor:

Central nervous system (CNS) disease in Abelson virus-induced leukemia

In the original description and isolation of the murine Abelson leukemia virus, we described a "massive degree of meningeal involvement" as a characteristic of the disease process.1,2 As in the Bcr/Abl murine bone marrow transduction and transplantation model, the latent period to tumor appearance was very short. We suggested that the meningeal disease could serve as a model for testing chemotherapy.

Herbert T. Abelson

Correspondence: Herbert T. Abelson, Department of Pediatrics, University of Chicago, 5841 South Maryland Ave, MC 1051 (C-120), Chicago, IL 60637; e-mail: habelson{at}peds.bsd.uchicago.edu

References

  1. Abelson HT, Rabstein LS. Lymphosarcoma: virus-induced thymic-independent disease in mice Cancer Res. 1970;30: 2213-2222.[Abstract/Free Full Text]

  2. Rabstein S, Gazdar AF, Chopra HC, Abelson HT. Early morphological changes associated with infection by a murine nonthymic lymphatic tumor virus. J Natl Cancer Inst. 1971;46: 481-491.[Medline] [Order article via Infotrieve]


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This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
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PubMed
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Right arrow Articles by Abelson, H. T.
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