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Blood, 15 September 2003, Vol. 102, No. 6, pp. 2312 To the editor:An update on how to treat chronic GVHDWe realized recently that the regimen described for the administration of calcineurin inhibitor for treatment of chronic graft-versus-host disease (GVHD)1 is discrepant from current practice. Previously, we used an alternate-day regimen of calcineurin inhibitor administration,2,3 but we now administer cyclosporine or tacrolimus twice daily for treatment of chronic GVHD. Although results with the 2 regimens have not been formally compared, this change was based primarily on pharmacokinetic considerations.
Correspondence: Mary E. D. Flowers, FHCRC, 1100 Fairview Ave. N., Seattle WA 98109
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