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Blood, 15 September 2003, Vol. 102, No. 6, pp. 2312

CORRESPONDENCE

To the editor:

An update on how to treat chronic GVHD

We realized recently that the regimen described for the administration of calcineurin inhibitor for treatment of chronic graft-versus-host disease (GVHD)1 is discrepant from current practice. Previously, we used an alternate-day regimen of calcineurin inhibitor administration,2,3 but we now administer cyclosporine or tacrolimus twice daily for treatment of chronic GVHD. Although results with the 2 regimens have not been formally compared, this change was based primarily on pharmacokinetic considerations.

Mary E. D. Flowers, Stephanie Lee, and Georgia Vogelsang

Correspondence: Mary E. D. Flowers, FHCRC, 1100 Fairview Ave. N., Seattle WA 98109

References

  1. Vogelsang GB. How I treat chronic graft-versus-host disease. Blood. 2001;97: 1196-1201.[Abstract/Free Full Text]

  2. Sullivan KM, Witherspoon RP, Storb R, et al. Alternating-day cyclosporine and prednisone for treatment of high-risk chronic graft-v-host disease. Blood. 1988; 72: 555-561.[Abstract/Free Full Text]

  3. Koc S, Leisenring W, Flowers MED, et al. Therapy for chronic graft-versus-host disease: a randomized trial comparing cyclosporine plus prednisone versus prednisone alone. Blood. 2002;100: 48-51.[Abstract/Free Full Text]


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