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Blood, 1 February 2005, Vol. 105, No. 3, pp. 918. This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Scott, E. W. Search for Related Content PubMed Articles by Scott, E. W. Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMOSTASIS Comment on Tepper et al, page 1068 EPC: the ischemia warrior of the bone marrow Edward W. Scott UNIVERSITY OF FLORIDA SHANDS CANCER CENTER Tepper and colleagues demonstrate that severe ischemia is the primary physiological trigger of circulating endothelial progenitor cell production by the bone marrow. Bone marrow–derived endothelial progenitor cells (BM-EPCs) were first described a little over 5 years ago, 1,2 heralding in a new paradigm of angiogenesis. Tepper and colleagues have developed a simple yet elegant new method to study the mechanisms of EPC production and recruitment from the bone marrow. One of the largest controversies surrounding BM-EPCs is why some models produce new vessels almost entirely derived from BM-EPCs3 and others produce vessels with significant yet low levels of EPC contribution.4 The new model induces a strong hypoxic gradient within a readily accessible skin flap that promotes predominantly BM-EPC–driven angiogenesis in the areas of the most severe ischemia, yet demonstrates very low BM-EPC contributions in areas with less ischemia (best highlighted in Figure 3C). The same contiguous new blood vessel is formed by different progenitor cells under differing levels of ischemia within the same skin flap. These exciting findings represent a simple elegant model that many can replicate and adopt to further delineate BM-EPC function. Contribution of bone marrow–derived EPCs to ischemia-induced neovascularization. See the complete figure in the article beginning on page 1068.   References Shi Q, Rafii S, Wu MH, et al. Evidence for circulating bone marrow-derived endothelial cells. Blood. 1998;92: 362-367.[Abstract/Free Full Text] Asahara T, Masuda H, Takahashi T, et al. Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circ Res. 1999;85: 221-228.[Abstract/Free Full Text] Grant MB, May WS, Caballero S, et al. Adult hematopoietic stem cells provide functional hemangioblast activity during retinal neovascularization. Nat Med. 2002;8: 607-612.[CrossRef][Medline] [Order article via Infotrieve] Bailey AS, Jiang S, Afentoulis M, et al. Transplanted adult hematopoietic stem cells differentiate into functional endothelial cells. Blood. 2004;103: 13-19.[Abstract/Free Full Text] CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Adult vasculogenesis occurs through in situ recruitment, proliferation, and tubulization of circulating bone marrow–derived cells Oren M. Tepper, Jennifer M. Capla, Robert D. Galiano, Daniel J. Ceradini, Matthew J. Callaghan, Mark E. Kleinman, and Geoffrey C. Gurtner Blood 2005 105: 1068-1077. [Abstract] [Full Text] [PDF] This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Scott, E. W. Search for Related Content PubMed Articles by Scott, E. W. Related Collections Related Article in Blood Online Social Bookmarking                   What's this?

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