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Blood, 1 February 2007, Vol. 109, No. 3, pp. 1336-1337. This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Folsom, A. R. Articles by Folsom, A. R. Search for Related Content PubMed PubMed Citation Articles by Folsom, A. R. Articles by Folsom, A. R. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CORRESPONDENCE Update on factor V Leiden association with venous thromboembolism in the LITE Study To the editor: In a previous article,1 we reported population-based findings from the Longitudinal Investigation of Thromboembolism Etiology (LITE) on factor V Leiden and risk of venous thromboembolism (VTE). We used a nested case-control design (301 new VTE cases and 630 controls through 1998) from the prospective Atherosclerosis Risk in Communities (ARIC) Study and Cardiovascular Health Study (CHS). The odds ratio, overall, for risk of VTE for carriers of factor V Leiden was 3.67 (95% CI, 2.20-6.12).1 We recently extended LITE to additional cases and controls through 2002. In the process, we discovered and corrected an error in the original selection of controls for ARIC that had caused us to oversample participants who had died into the control group for our earlier report. Compared with our published report, the updated sample of 502 cases and 1021 controls yielded an almost identical odds ratio for factor V Leiden of 3.46 (95% CI, 2.20-5.43). Genotype distributions and other odds ratios for factor V Leiden (Tables 1–2) are also similar to those in our original report's Tables 1–2.1 The estimate for African Americans remains quite imprecise from this large prospective study because of the infrequency of factor V Leiden in African Americans. View this table: [in this window] [in a new window]   Table 1. Frequency of factor V Leiden in VTE cases and controls, LITE   View this table: [in this window] [in a new window]   Table 2. Age-adjusted odds ratio and 95% CI for VTE in relation to factor V Leiden, 1987-2002, LITE   We were unable to repeat other measures in our original report1 (activated protein C resistance, factor V concentration, and HRZ haplotype) to confirm no influence of the control selection error. Nevertheless, these factor V Leiden results offer confidence of the accuracy of our original report.1 Authorship Correspondence: Aaron R. Folsom, University of Minnesota, School of Public Health, 1300 South Second St, Ste 300, Minneapolis, MN 55454-1015; e-mail: folsom{at}epi.umn.edu. Aaron R. Folsom, for the LITE Investigators References Folsom AR, Cushman M, Tsai MY, et al. A prospective study of venous thromboembolism in relation to factor V Leiden and related factors. Blood 2002; 99:2720–2725.[Abstract/Free Full Text] CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Folsom, A. R. Articles by Folsom, A. R. Search for Related Content PubMed PubMed Citation Articles by Folsom, A. R. Articles by Folsom, A. R. Social Bookmarking                   What's this?

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