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Blood, 1 October 2007, Vol. 110, No. 7, pp. 2770. This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Chen, G. L. Articles by Prchal, J. T. Search for Related Content PubMed Articles by Chen, G. L. Articles by Prchal, J. T. Related Collections Related Articles in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CORRESPONDENCE Response: X-chromosome inactivation and autoimmunity We thank Dr Ozcelik for his careful reading of our review and his thoughtful letter. Dr Ozcelik raises the issue of nonequivalence of monosomy X frequency and X-chromosome inactivation pattern (XCIP). The first refers to the proportion of cells with a single X chromosome, wherein transcription occurs from the lone X chromosome. The second refers to the ratio of inactivated maternal to paternal X chromosome, wherein transcription does not occur from the inactivated chromosome. We agree that although frequency of monosomy X and XCIP are different, both estimate the degree of inequality in X-chromosome dosage. Thus, while direct comparisons may not be possible, it is reasonable to use them as indices for processes inactivating the X chromosome. Dr Ozcelik references 2 unpublished studies refuting XCIP skewing in primary biliary cirrhosis. These studies are unavailable to us and we are unable to comment on them. Finally, our comments about age-related XCIP and the pathogenesis of certain autoimmune diseases have been misinterpreted by Dr Ozcelik. Certainly, many of these autoimmune diseases tend to be more prevalent in older rather than younger patients, and the increased prevalence of XCIP with age suggests there may be some relationship between the two. However, we clearly point out that "no studies have formally linked age related XCIP skewing with the development of autoimmune disease," and that this topic "deserves further research."1 Thus, we read with interest Dr Ozcelik's further thoughts on unequal X-chromosome expression and autoimmune disease.    Authorship Top Authorship References   Conflict-of-interest disclosure: The authors declare no competing financial interests. Correspondence: Josef T. Prchal, University of Utah, School of Medicine, 30 N 1900 E, Room 4C416, Salt Lake City, UT 84112; e-mail: josef.prchal{at}hsc.utah.edu. George L. Chen, and Josef T. Prchal    References Top Authorship References   Chen GL and Prchal JT. X linked clonality testing: interpretation and limitations. Blood Prepublished online April 13, 2007, as DOI 10.1182/blood-2006-09-018655.[Abstract/Free Full Text] CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Articles in Blood Online: X-linked clonality testing and autoimmune diseases Tayfun Ozcelik Blood 2007 110: 2769. [Full Text] [PDF] X-linked clonality testing: interpretation and limitations George L. Chen and Josef T. Prchal Blood 2007 110: 1411-1419. [Abstract] [Full Text] [PDF] This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Chen, G. L. Articles by Prchal, J. T. Search for Related Content PubMed Articles by Chen, G. L. Articles by Prchal, J. T. Related Collections Related Articles in Blood Online Social Bookmarking                   What's this?

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