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Blood, 1 November 2007, Vol. 110, No. 9, pp. 3096.
BLOOD WORK Anemia and an elevation of MCV
A 35-year-old woman was admitted for pleuritic chest pain. The hospitalist noted mild anemia (hemoglobin 91 g/L) and an elevated mean corpuscular volume (MCV) of 102 on the laboratory report. B12 and folic acid levels were ordered and were normal. A hematologist was requested. The patient had 2 recent episodes of jaundice diagnosed as infectious mononucleosis. Arthralgias had also been present. The family history was negative. On examination, the spleen was palpable. The peripheral smear showed spherocytes and a nucleated red cell. Furthermore, the elevation of MCV was related to reticulocytosis. One laboratory test was ordered: the direct Coombs test. Both the immunoglobulin G (IgG) and C3 Coombs tests were positive. A rheumatologic laboratory assessment made the patient's previous jaundice, arthralgias, and the current Coombs positive spherocytic hemolytic anemia consistent with systemic lupus erythrematosis.
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