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Blood, 1 June 2008, Vol. 111, No. 11, pp. 5268.
Lenalidomide: what is the right dose in CLL?THE OHIO STATE UNIVERSITY
Ferrajoli and colleagues present the results of a phase 2 study in which lenalidomide was administered by continuous daily dosing to 44 patients with relapsed CLL. Clinical activity (ORR 32%, CR 7%) was observed, and responses were seen in patients with poor-risk cytogenetic abnormalities and unmutated IgVH. However, the mechanism(s) of action and the optimal dosing schedule of lenalidomide remain undefined.
Chanan-Khan and colleagues administered lenalidomide at a dose of 25 mg daily on days 1 to 21 every 28 days to 45 patients with relapsed chronic lymphocytic leukemia (CLL).3 Lenalidomide was active (overall response rate [ORR] 47%, complete remission [CR] 9%), although hematologic toxicity at grades 3 and 4 was significant, and 2 patients developed tumor lysis syndrome. Furthermore, 58% of patients experienced a unique tumor flare reaction, occurring within 24 hours of the first dose and lasting a median of 14 days, which was not observed in MM or MDS. In this issue of Blood, Ferrajoli and colleagues present the results of a phase 2 study in which lenalidomide was administered at 10 mg per day by continuous daily dosing to 44 patients with relapsed CLL. The dose could be escalated 5 mg every 28 days up to 25 mg daily, but significant hematologic toxicity resulted in 10 mg being the median delivered dose. The authors observed an ORR of 32% (CR 7%), with activity apparent in patients with high-risk cytogenetic abnormalities (ORR 31%) and unmutated IgVH (ORR 25%), although 6 to 9 months were needed to achieve optimal response. In contrast to agents such as fludarabine and alemtuzumab, lenalidomide caused no reduction in T-cell counts, although 1 patient died of pneumonia and 1 patient died of mucormycosis during cycle 1, perhaps due to prior immunosuppression.
Thirteen patients (30%) developed tumor flare reactions, which were treated with a 6-day solumedrol pack; lymph node size greater than 5 cm was the only identified risk factor. Clinical response did not depend upon development of tumor flare. In contrast to its ability to reduce IL-6 production in MM,4 which may be critical to its activity in that disease, lenalidomide did not reduce IL-6 levels in responding CLL patients, and actually induced a dramatic increase in IL-6 in nonresponders. No significant change in TNF- The article by Ferrajoli and colleagues indicates that continuous low-dose lenalidomide may be as effective as an interrupted schedule using higher doses. At 5 mg daily, 3 of 11 patients responded, and a CR was observed at 10 mg daily. However, this study also illustrates the toxicity of lenalidomide in heavily treated, relapsed CLL patients. Despite a median dose of 10 mg daily, significant hematologic toxicity was observed, and 30% of patients developed tumor flare reactions. Although lenalidomide appears to exert an immunostimulatory effect, its mechanism of action in CLL remains unclear and requires further investigation. Although lenalidomide is clearly active in CLL, more clinical studies are needed to define the optimal dosing schedule and confirm the safety of lenalidomide in treating this malignancy.
Footnotes
Conflict-of-interest disclosure: The author has served on advisory boards for Celgene, which produces and licenses lenalidomide (Revlimid).
REFERENCES
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| Copyright © 2008 by American Society of Hematology Online ISSN: 1528-0020 | |||||||||
was observed with therapy, although responders had a mean baseline TNF-