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Blood, 1 July 2008, Vol. 112, No. 1, pp. 210.

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CORRESPONDENCE

Response: Natalizumab-induced mobilization of CD34+ hematopoietic progenitor cells

We thank Vuaillat et al for reading our paper1 carefully with great interest.

Within this short correspondence we hope to elucidate the questions raised:

  1. All 5 untreated patients met both the McDonald and the Barkhoff criteria and were diagnosed between 2002 and 2006 with the relapsing-remitting form of the disease. Therefore they had experienced more than one relapse episode of the disease.
  2. The patients had the following blood-circulating CD34+ counts: 0.57/µL; 0.8/µL; 1.06/µL; 1.44/µL and 1.68/µL.
  3. For CD34+ subset analysis we performed dual-color phenotyping, and all circulating CD34+ cells belonged to the subset of more committed progenitors coexpressing CD38.


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Conflict-of-interest disclosure: The author declares no competing financial interests.

Correspondence: Fabian Zohren, Heinrich Heine University, Moorenstr 5, Duesseldorf, Germany 40225; e-mail: fabian.zohren{at}med.uni-duesseldorf.de.

Fabian Zohren


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  1. Zohren F, Toutzaris D, Klärner V, Hartung H-P, Kieseier B, Haas R. The monoclonal anti–VLA-4 antibody natalizumab mobilizes CD34+ hematopoietic progenitor cells in humans. Blood. 2008;111:3893–3895.[Abstract/Free Full Text]


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The monoclonal anti–VLA-4 antibody natalizumab mobilizes CD34+ hematopoietic progenitor cells in humans
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Blood 2008 111: 3893-3895. [Abstract] [Full Text] [PDF]




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