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Blood, 5 March 2009, Vol. 113, No. 10, pp. 2125. This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Search for Related Content Related Collections Transplantation Blood Work Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  BLOOD WORK Howell-Jolly bodies in patients with chronic GVHD View larger version (78K): [in this window] [in a new window]   A 43-year-old man with history of relapsed diffuse large B-cell lymphoma was admitted for fever and cough. He had a history of prior autologous peripheral blood stem cell transplantation (PBSCT) 10 years earlier with subsequent disease progression. An allogeneic PBSCT from a HLA-matched unrelated donor was performed. His disease was in remission when he developed extensive chronic graft-versus-host disease (cGVHD) of skin and mouth. CT chest scan showed patchy consolidations. His peripheral blood showed Howell-Jolly bodies (red arrows). Subsequently, the patient died of pneumonia and progressive renal failure. Chronic GVHD, which is associated with severe immune dysfunction and increased frequency of infections, may show numerous Howell-Jolly bodies. Normally, Howell-Jolly bodies are remnants of the erythroblast nucleus that are removed by the spleen. In patients with cGVHD, their appearance is associated with functional asplenia (Kalhs et al. Ann Intern Med. 1988;109:461-464).     The above image was first published in the ASH IMAGE BANK, a reference and teaching tool that is continually updated with new atlas images and images of case studies. For more information or to contribute to the Image Bank, visit ashimagebank.hematologylibrary.org. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Search for Related Content Related Collections Transplantation Blood Work Social Bookmarking                   What's this?

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