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Blood, 28 May 2009, Vol. 113, No. 22, pp. 5369-5370.
Be fruitful, multiply, and replenishUNIVERSITY MEDICAL CENTER UTRECHT
In this issue, Bains and colleagues show that T-cell proliferation plays a major role in the establishment of the T-cell pool, even in the very young, despite their high thymus output.
In this issue of Blood, Bains et al4 present a mathematical model that integrates various experimental findings on naive T cells and T-cell receptor excision circle (TREC) dynamics 5 as well as thymus output6 in young humans up to 20 years of age. They show that at all ages—even in the very young, when thymus output is still at its maximum—the contribution of peripheral T-cell proliferation to the establishment of the naive T-cell pool prevails over thymus production. These findings are in line with the observation that in young healthy people, naive T-cell numbers increase while total TREC numbers do not, implying that peripheral T-cell proliferation contributes considerably to the establishment of the naive T-cell pool in early childhood.3 Combining the decreasing output of the thymus with the increase of total body naive CD4+ T-cell numbers during childhood, one would perhaps expect the rate of peripheral T-cell proliferation to increase with age. The study by Bains et al shows, however, that the rate of peripheral T-cell proliferation decreases when thymus output declines, concomitant with increasing naive T-lymphocyte residence times. Despite the undisputed role of thymus involution during aging, the contribution of peripheral T-cell proliferation to the establishment of the naive T-cell pool is thus much larger than previously thought, especially in the very young. Bains et al thereby demonstrate the risk of indirect intuitive reasoning and the strength of collective analysis of experimental data with the help of mathematical modeling.7 The strength of their modeling approach is that it makes no a priori assumptions on how lymphocyte proliferation and death rates are affected by age or by total lymphocyte numbers. Provided that the average TREC content of naive T cells stays constant between birth and the age of 20, no other conclusions could be drawn from the data. The amount of naive T-cell TREC content data are, however, very limited, and TREC measurements are notorious for interassay variation. Therefore, this study also calls for more extensive measurement of TREC changes in naive T cells during childhood and warrants more direct measures of T-cell death rates in children, for example, based on stable-isotope labeling. The large contribution of peripheral T-cell proliferation to the establishment of the naive T-cell pool in children goes against current beliefs, which may in part stem from improper extrapolation of insights obtained from young thymectomized mice. Even though lymphocyte dynamics in young and old mice are widely believed to be comparable to those in young and old humans, there is little data showing that such extrapolations can indeed safely be made. Similar comparative studies in mice of different ages and in humans older than 20 years of age should point out whether the processes responsible for the establishment and maintenance of the naive T-cell pool in mice and men are indeed comparable.
Acknowledgment:
J.B. was financially supported by The Netherlands Organisation for Scientific Research (NWO grant 836.07.002).
Footnotes
Conflict-of-interest disclosure: The authors declare no competing financial interests.
REFERENCES
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| Copyright © 2009 by American Society of Hematology Online ISSN: 1528-0020 | |||||||||
