|
|
Blood, Vol. 102, Issue 1, 262-268, July 1, 2003
Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation
Blood Ferrando et al.
102: 262
Supplemental materials for: Ferrando et al, Vol 102, Issue 1, 262-268
Files in this Data Supplement:
- Table S3. Genes positively and negatively associated with the presence of the MLL-ENL rearrangement in T-ALL (PDF file, 320 KB) -
The top 100 “nearest-neighbor” genes identified using the signal-to-noise metric as positively or negatively associated with the presence of the MLL-ENL rearrangement in the 39 T-ALL cases analyzed are listed.
- Table S1. Clinical and laboratory data of T-cell ALL cases (XLS file, 51 KB)
-
Sample identifiers, oncogene categories, karyotype results, and p16/INK4A-p14/ARF deletion status as determined by quantitative PCR, immunophenotype data, clinical data, and oncogene expression levels determined by quantitative PCR are listed. The correspondence of these cases with the figures of the manuscript is listed in the far right columns.
- Table S2. Clinical and laboratory data of B-precursor ALL cases (XLS file, 15 KB)
-
Sample identifiers, karyotype/FISH results, sample source (bone marrow BM versus peripheral blood PB), patient age at diagnosis, and nature of the sample (diagnostic versus relapse) of the 41 B-precursor ALL cases analyzed is listed. The correspondence of these cases with the figures of the manuscript is listed in the far right columns.
- Figure S1. Relative gene expression of proliferation associated genes in B-precursor ALL and in MLL B-ALL cases (JPG, 1.61 MB)
-
Each row represents a gene and each column represents a sample. Red color represents expression higher than the mean, and blue color represents lower than the mean as illustrated in the bar at the bottom that shows the correlation between shifts in color and differences in gene expression, from –3 to +3 standard deviations.
- Figure S2. MLL-ENL associated genes in B-precursor ALL (JPG, 1.49 MB)
-
The top 100 genes most closely associated with MLL-ENL B-ALL versus B-precursor ALL are shown. Each row represents a gene, and each column represents a sample. Red color represents expression higher than the mean, and blue color represents lower than the mean as illustrated in the bar at the bottom that shows the correlation between shifts in color and differences in gene expression, from –3 to +3 standard deviations.
- Figure S3. Gene expression levels of myeloid genes in T-ALL (JPG, 227 KB)
-
Absolute fluorescence values for representative myeloid genes indicating low levels of expression in MLL T-ALL samples and consistent up-regulation in the only T-ALL sample containing a FLT3 kinase internal tandem duplication activating mutation (labeled in red).
|
|
