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Blood, Vol. 104, Issue 4, 1137-1144, August 15, 2004
Suppression of leukemia expressing wild-type or ITD-mutant FLT3 receptor by a fully human anti-FLT3 neutralizing antibody
Blood Li et al.
104: 1137
Supplemental materials for: Li et al, Vol 104, Issue 4, 1137-1144
Files in this Data Supplement:
- Document 1. Additional data on the mechanism of action of the anti-FLT3 antibody IMC-EB10 (PDF, 176 KB) -
This document contains 3 figures that provide additional data on the mechanism of action of the anti-FLT3 antibody IMC-EB10. Contents include detailed descriptions of the methods and results of these experiments. Figure S1 shows that IMC-EB10 does not induce apoptosis in EOL-1 and BaF3-ITD leukemia cells. Figure S2 shows that IMC-EB10 does not affect the expression of the FIP1L1-PDGFRA fusion gene in EOL-1 cells. Figure S3 shows that incubation with IMC-EB10 antibody causes the internalization of FLT3 receptor on BaF3-ITD cells, suggesting that antibody-mediated internalization and the resulting down-modulation of surface FLT3 receptor may contribute to the anti–FLT3-ITD activity observed in the BaF3-ITD cell line.
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