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Blood, Vol. 107, Issue 11, 4364-4374, June 1, 2006
Functional analysis of zebrafish microfibril-associated glycoprotein-1 (Magp1) in vivo reveals roles for microfibrils in vascular development and function
Blood Chen et al.
107: 4364
Supplemental materials for: Chen et al
Files in this Data Supplement:
- Figure S1 (JPG, 45 KB)
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Red blood cells remain confined in the dilated vessels in MAGP-1 morphant embryos. Transgenic Fli-1:EGFP/Gata-1: dsRED) fish embryos were used to visualize the vasculature and circulating red blood cells. Anterior view of a wild-type embryo under the FITC channel (A) , showing the cranial vessels as labeled by EGFP and under the rhodamine channel (B), showing the circulating red blood cells in the cranial vasculature as labelled by dsRED. (C) Anterior view of an MAGP-1 morphant embryo, showing enlarged cranial vessels (arrowheads) as viewed under the FITC channel. (D) Under the rhodamine channel, the same MAGP-1 morphant embryo shows accumulation of red blood cells in the dilated vessels (arrowheads). (E) An overlay image of (C) and (D) showing the confinement of red blood cells within the dilated vessels. No extravasation of red blood cells into extravascular space is observed. Original magnification: ×10. Anterior is to the left.
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