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Blood, Vol. 107, Issue 6, 2477-2485, March 15, 2006
Array comparative genomic hybridization reveals genomic copy number changes associated with outcome in diffuse large B-cell lymphomas
Blood Chen et al.
107: 2477
Supplemental Methods and Tables for: Chaganti et al
Files in this Data Supplement:
- Supplemental Methods (PDF, 208 KB) -
In this document, a detailed description of the modified circular binary segmentation (CBS) algorithm used to identify segmental gains and losses along autosomes is provided, as well as the method that was utilized to determine common regions of gain and loss of genomic material across the entire group of specimens. In addition, a detailed description is provided for the classification of specimens into DLBCL expression subtypes according to the method of Wright et al.
- Table S1 (XLS, 79 KB)
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For each of the 64 patients in the study, the respective clinical characteristics are provided and coded as described in comments attached to each column heading. The immunohistochemical staining scores for each of four antibodies is provided, with 1=positive staining, and 0=negative staining, with the latter three used in the determination of the IHC Subtype. The Subtype determined for each available specimen by array expression analysis is also given. Finally, the presence or absence calls of the common regions/subregions of DNA copy number gain/loss in Table 2 are given for each specimen where 1=change present, and 0=change not present.
- Table S2 (XLS, 2.44 MB)
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For each of the 64 patients in the study, the assignments for each autosomal clone on the array used in the analyses are provided. Gains/losses were identified either as segmental or singleton copy number changes. NA indicates clones for which a normal/gain/loss call could not be made for reasons described in the Supplemental Methods.
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