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Blood, Vol. 107, Issue 8, 3330-3338, April 15, 2006
ATRA resolves the differentiation block in t(15;17) acute myeloid leukemia by restoring PU.1 expression
Blood Mueller et al.
107: 3330
Supplemental materials for: Mueller et al
Files in this Data Supplement:
- Table S1. Clinical characteristics of an APL patient treated with ATRA (PDF, 14.7 KB) -
+ The patient analyzed in Figure 5B with APL at diagnosis was treated with 45mg/m2/day of ATRA alone. No concomitant chemotherapy was given. Depicted are daily values of peripheral blood cells.
* Neutrophils are given as percentage of all blood leukocytes.
"Leukemic blasts are indicated as percentage of all blood leukocytes.
G/l: 109 per liter.
g/l: gram per liter.
n.d.: not determined.
- Table S2. Clinical characteristics of 141 AML patients (PDF, 11.9 KB) -
Clinical characteristics at diagnosis of AML of the patients analyzed in Figure 6c. Ficoll separation was performed in all cases. +LDH: lactate dehydrogenase, normal: <480 U per litre; *Source of leukemic blasts at diagnosis was peripheral blood in 22% of all cases. The percentage of blasts in the blood was at least 70% of all leukocytes in those cases where blood was used as source of blasts. "Others involved AML with t(11q23) in six patients; with —7 in three patients; with —5q in three patients; with inv(3) in one patient; with t(11;17) in one patient; and with t(3;12) in one patient. ˆFLT3/ITD: Internal tandem duplications of the FLT3 gene.
G/l: 109 per liter.
g/l: gram per liter.
- Figure S1. OCT 1 mRNA expression of 141 AML patient samples of all FAB subtypes as assessed by real-time PCR (PDF, 11.2 KB) -
The bars represent mean values of OCT 1/GAPDH ratios, given as fold induction of the result of M0 patients.
- Figure S2. CEBPA, CEBPB, and CEBPE mRNA expression of 141 AML patient samples of all FAB subtypes as assessed by real-time PCR (PDF, 17.4 KB) -
The bars represent mean values of OCT 1/GAPDH ratios, given as fold induction of the result of M0 patients.
- Figure S3 (PDF, 12.3 KB) -
HT-PER and HT-V cells were treated with estradiol (+Est), with ATRA (+ATRA) or were cultured without stimulation (no) and counted at day 0, at day 2, and at day 4. The Y-axis indicates the number of cells (x106 cells/ml), and the X-axis depicts time points day 0, 2, and 4.
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