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Blood, Vol. 107, Issue 12, 4678-4686, June 15, 2006
The SCL relative LYL-1 is required for fetal and adult hematopoietic stem cell function and B-cell differentiation
Blood Capron et al.
107: 4678
Supplemental materials for: Capron et al
Files in this Data Supplement:
- Figure S1. Competitive repopulation assays by lyl-1—/— E14 FL cells show defects in multilineage hematopoietic repopulation (PDF, 54.8 KB) -
5×106, 1×106, 5×105 Ly5.2 E14 FL lyl-1+/+ (wt-5, wt-1 and wt-0.5, respectively) or lyl-1—/— (KO-5, KO-1 and KO-0.5, respectively) cells were mixed with 1×106 Ly5.1 BM cells and transplanted into lethally irradiated C57B6 Ly5.1 mice. Diagrams represent the percentage of donor-derived cells in PB (A) and BM (B) of reconstituted mice (6 mice per group) at 4 and 24 weeks after injection. An example of two independent experiments is shown. Data represent means ± SEM, * p<0.05. The contribution of donor-derived cells to each reconstituted lineage is determined by analyzing the percentage of CD45.2+,B220+; CD45.2+,CD3+ and CD45.2+,GR-1/MAC-1+ cells (C and D). Data represent means ± SEM of two independent experiments, (* p<0.05).
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