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Next Article 
Blood, Vol. 92 No. 2 (July 15), 1998:
pp. 345-344
Growth Factors and Hematopoietic Cell Fate. A New
Feature: Controversies in Hematology
By
Kenneth Kaushansky
WITH THIS ISSUE OF BLOOD we
launch a new feature, Controversies in Hematology. The series
is designed to identify both long-standing and relatively recent topics
in Hematology and Oncology on which considerably diverging opinions
exist, and to highlight the critical data supporting each view. The
format is one of point and counterpoint. Each discussant will have an
opportunity to put forth the critical arguments supporting their
position. The papers will be exchanged and each author then allowed to
rebut the arguments of the opposing discussant. We feel that this
format will allow the readership to quickly appreciate the question
being addressed and the nature of the evidence in support of each view.
The reader is then left to his or her own conclusions. We also hope
each Controversy will evoke discussion and stimulate additional
investigation in the field.
The inaugural chapter in the series asks what are the mechanisms
responsible for commitment of multipotent hematopoietic progenitors to
cells of each blood lineage. Evidence from many quarters indicate that
growth factors are essential for hematopoietic development. However,
the precise role played by these proteins, whether to direct
multipotent cells down a particular cellular pathway or to merely
support the survival of cells that have intrinsically selected a
specific hematopoietic lineage, remains
controversial.
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