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Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents Blood, 1 September 2000, Vol. 96, No. 5, pp. 2002-2003 CORRESPONDENCE To the editor: The platelet glycoprotein Ia C807T polymorphism as risk factor for coronary catheter interventions In a recent paper, the results of a carefully performed study on the association between the glycoprotein (GP) Ia C807T polymorphism and procedural risk after coronary artery stenting were reported.1 The authors concluded that the 807T genotype, which is associated with higher platelet-surface expression of GP Ia/IIa, had no significant influence on major adverse events occurring after coronary artery stenting.1 Because the implantation of stents induces marked platelet activation, we wondered if these results might also apply to coronary interventions without stent implantation, that is, plain angioplasty (PTCA) and directional coronary atherectomy (DCA). In a prospective study of 673 patients who underwent coronary interventions (PTCA, DCA, and stenting), we performed genotyping for the GP Ia C807T polymorphism and followed the patients for a 30-day composite endpoint, including need for target vessel revascularization (repeat PTCA or bypass grafting), myocardial infarction, and death. Operational techniques, indications for coronary interventions, baseline, and the patients' clinical characteristics have been described in detail elsewhere.2 Genotyping (by PCR/RFLP according to Kritzik et al3) was successful for 272 patients who underwent PTCA, for 104 with DCA, and for 276 who were treated by stenting. Genotype distribution was CC in 35.3%, CT in 49.7%, and TT in 15.0%, results comparable to reported data.1 Our results regarding early complications after stent implantation confirm those reported by von Beckerath et al.1 In addition, our data provide evidence that the GP Ia 807T genotype is, likewise, not a risk factor for adverse events following PTCA and DCA (Table). Data did not change after construction of a multivariate model that included baseline risk factors, coagulation parameters, and procedural determinants. We conclude from our data, together with other results reported previously,1 that the GP Ia 807T genotype does not predict adverse outcome after coronary interventions, regardless of whether or not stents are implanted.                                View this table: [in this window] [in a new window]   Major adverse events during the first 30 days after coronary intervention according to GP Ia C807T genotype Christian Meisel, Ingolf Cascorbi, Antje Herrmann, and Ivar Roots Institute of Clinical Pharmacology Charité University Medical Center Humboldt University of Berlin Berlin, Germany Michael Laule, Verena Stangl, and Karl Stangl Department of Cardiology Charité University Medical Center Humboldt University of Berlin Berlin, Germany   Supported by German Ministry of Education, Science, Research, and Technology grant 01 GG 9845/5. References 1. von Beckerath N, Koch W, Mehilli J, et al. Glycoprotein Ia gene C807T polymorphism and risk for major adverse cardiac events within the first 30 days after coronary artery stenting. Blood. 2000;95:3297-3301[Abstract/Free Full Text]. 2. Laule M, Cascorbi I, Stangl V, et al. A1/A2 polymorphism of glycoprotein IIIa and association with excess procedural risk for coronary catheter interventions: a case-control study. Lancet. 1999;253:708-712. 3. Kritzik M, Savage B, Nugent DJ, et al. Nucleotide polymorphisms in the alpha2 gene define multiple alleles that are associated with differences in platelet alpha2 beta1 density. Blood. 1998;92:2382-2388[Abstract/Free Full Text]. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Glycoprotein Ia gene C807T polymorphism and risk for major adverse cardiac events within the first 30 days after coronary artery stenting Nicolas von Beckerath, Werner Koch, Julinda Mehilli, Corinna Böttiger, Albert Schömig, and Adnan Kastrati Blood 2000 95: 3297-3301. [Abstract] [Full Text] [PDF] This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Meisel, C. Articles by Stangl, K. Search for Related Content PubMed Articles by Meisel, C. Articles by Stangl, K. Related Collections Related Article in Blood Online Social Bookmarking                   What's this?

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