|
|||||||||
|
|
|
|
|
|
|
|
|
|
|
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
From the First Department of Internal Medicine,
University of Athens School of Medicine, and the Thalassemia Unit,
Laiko General Hospital; and the Thalassemia Unit, Aghia Sophia
Children's Hospital, Athens, Greece.
Cardiac complications in 110 patients (mean age, 32.5 ± 11.4
years) with thalassemia intermedia (TI) were studied. Sixty-seven (60.9%) of them had not been transfused or were minimally transfused (group A). The rest had started transfusions after the age of 5 years
(mean, 15.1 ± 10.1 years), initially on demand and later more
frequently (group B). Overall mean hemoglobin and ferritin levels were
9.1 ± 1.1 g/dL and 1657 ± 1477 ng/mL, respectively. Seventy-six
healthy controls were also studied. The investigation included thorough
history taking, clinical examination, electrocardiography, chest
radiograph, and full resting echocardiography. Of 110 patients, 6 (5.4%) had congestive heart failure (CHF), and 9 (8.1%) had a history
of acute pericarditis. Echocardiography showed pericardial thickening,
with or without effusion, in 34.5% of the patients. Valvular
involvement included leaflet thickening (48.1%), endocardial calcification (20.9%), and left-sided valve regurgitation (aortic, 15.4%; mitral, 47.2%). All patients had normal left ventricular contractility (fractional shortening, 0.43 ± 0.05), and high cardiac output (CO; 9.34 ± 2.28 L/min). Pulmonary hypertension (PHT), defined as Doppler peak systolic tricuspid gradient greater than 30 mm
Hg, developed in 65 patients (59.1%). PHT correlated positively with
age and CO and did not differ significantly between groups. Cardiac
catheterization in the 6 patients with CHF revealed severe PHT,
increased pulmonary resistance (PVR), and normal capillary wedge
pressure. It was concluded that in patients with TI, the heart is
primarily affected by PHT, which is the leading cause of CHF. High CO
resulting from chronic tissue hypoxia and increased PVR are the main
contributing factors. Doppler tricuspid gradient measurement should be
considered, in addition to other factors, when determining the value of
transfusion therapy for patients with TI.
(Blood. 2001;97:3411-3416) Cardiac complications are a main feature of the clinical spectrum of
Pulmonary hypertension and right ventricle failure have been reported
in 7 patients with TI.4 The purpose of the present study
was to determine the form and severity of cardiac abnormalities in a
large group of patients with TI, thereby extending and substantiating systematically the results of that original case report.
Study population
Cardiac investigation was performed as part of the routine follow-up.
In patients who underwent transfusion therapy, it was scheduled for the
day before transfusion. The standard evaluation consisted of a thorough
medical history and physical examination, electrocardiography, chest
radiographs, and echocardiography. Patients with congestive heart
failure (CHF) also underwent right cardiac catheterization 5 days after
cardioactive medication was discontinued.
Seventy-six age- and sex-matched control subjects were randomly
selected; they did not smoke and had no evidence of anemia or of liver,
respiratory, or cardiovascular disease. Although patients with TM were
initially considered as control subjects, they were not chosen because
our patients with TM could not be age-matched with patients with TI.
Echocardiography
Pericardial thickening was considered present if pericardial echoes consisted of at least 2 separate lines and were more than 4 mm thick,5 whereas pericardial effusion was evaluated visually using 2-dimensional echocardiography.6 Valvular leaflet thickening was defined as dense echo reflection (thicker than 4 mm for the mitral and tricuspid valves and 3 mm for the aortic and pulmonary valves), and endocardial calcification was defined as a brighter echo density, with or without acoustic shadowing, at minimal gain settings. Valvular regurgitation was graded semiquantitatively by color Doppler,7,8 while mitral valve prolapse (MVP) was diagnosed using the criteria of Levine et al.9 Cardiac dimensions were measured according to the recommendations of the American Society of Echocardiography (ASE) by M-mode,10 and 2-dimensional echo was used wherever M-mode measurements were considered unreliable.11 LVMass was calculated using the ASE cube formula as corrected by Devereux et al.12 LVMass Index was also calculated by dividing LVMass by body surface area (BSA). Left ventricle volume and, subsequently, LV ejection fraction, stroke volume (SV), and cardiac output (CO), were estimated by the method of discs according to ASE recommendations and using apical 2- and 4-chamber views.13 Stroke index and cardiac index were calculated as SV/BSA and CO/BSA, respectively. Diastolic LV function was evaluated by Doppler parameters, including early (E) and late (A) diastolic peak flow velocities, E/A ratio, deceleration time of E wave (DT),14 and LV isovolumic relaxation time (IVRT).15 Assessment of pulmonary artery pressure and pulmonary vascular resistance (PVR) was provided by Doppler recording of the systolic pulmonary flow and the measurement of pulmonary acceleration time (PAT) and PAT-to-right ventricular ejection time ratio (PAT/RVET).16 In addition, tricuspid valve continuous-wave Doppler tracing was obtained in patients with tricuspid regurgitation to measure peak systolic right ventricular to right atrial pressure gradient (TG). This is considered the most reliable noninvasive method of estimating pulmonary artery pressure.17 Measurements were obtained at maximal velocity jet; TG was calculated according to the simplified Bernoulli equation.17 Apical 4-chamber, parasternal short-axis, and parasternal long-axis views were used while the subject suspended breathing at the end of a normal expiration, and 3 cardiac cycles were averaged. Statistical analysis Statistical analysis was performed using the SPSS 7.5 statistical software package. Continuous variables were expressed as mean ± SD. P < .05 was considered statistically significant. Student t and 2 tests were used
to compare variables between patients and controls or between patient
groups. Bivariate correlation and multivariate regression analyses were
used to investigate for potential relations between variables.
Congestive heart failure developed in 6 (5.4%) patients aged 41.6 ± 11.6 years. Nine (8.1%) patients had at least one episode of acute pericarditis at a mean age of 25.7 ± 14.4 years. None had a history of rheumatic fever. Thirty-two (29%) patients had hepatomegaly greater than 3 cm below the right costal border. All patients who did not undergo splenectomy had splenomegaly. Cardiac auscultation revealed a systolic murmur over the cardiac base or apex in most (61.8%) patients; midsystolic click and fourth heart sound were found in 7 (6.3%) and 5 (4.5%) patients, respectively. Gallop rhythm was present in 4 (3.6%) patients, all of whom had CHF. All patients were normotensive, with mean systolic and diastolic blood pressure levels of 120 ± 15 and 80 ± 7 mm Hg, respectively. Electrocardiography According to more recent criteria,18 left and right ventricular hypertrophy were present in 15 (13.6%) and 8 (7.2%) patients, respectively, and 7 (6.3%) had biventricular hypertrophy. In addition, 7 (6.3%) patients had right QRS axis deviation, 9 (8.1%) had right bundle branch block, and 1 had complete (third-degree) atrioventricular block. Premature atrial contraction (PAC) was observed in 18 (16.3%) patients, and atrial fibrillation was observed in 7 (6.3%) patients aged 45.8 ± 12.3 years.Chest radiography Chest radiographs revealed increased cardiothoracic index levels in 54 (49%) patients. Eighteen (16.3%) had prominent pulmonary arteries. Signs of obvious bone marrow expansion were present in 25 (22.7%) patients and included intrathoracic extramedullary hemopoietic masses in 21 (19%) patients and widening of ribs in 10 (9%) patients (Figure 1). Pericardial calcification was found in a 42-year-old patient with a history of pericarditis but no history of tuberculosis and negative findings on the Mantoux test (Figure 2).
Echocardiography The occurrence of pericardial and valvular abnormalities was significantly higher in patients than in controls. Pericardial findings consisted of thickening in 38 patients (34.5% vs 9.2% in controls; P < .001), 16 of whom also displayed small or moderate effusion with no acute symptoms. Of the patients with pericardial abnormalities, only 6 had histories of pericarditis. Valvular leaflet thickening was found in 53 patients (48.1% vs 14.4% in controls; P < .001), whereas endocardial calcification of variable extent, located at mitral annulus and leaflets, papillary muscles, and aortic valve, was present in 23 patients (20.9% vs 1.3% in controls; P < .001). Three patients with intense endocardial calcification involving the aortic valve had peak systolic aortic gradients of 23, 25, and 38 mm Hg, respectively, in continuous-wave Doppler measurement; a fourth patient had third-degree atrioventricular block, and a pacemaker was implanted. Regurgitation was encountered at all valvular sites. Left-sided valvular regurgitation, usually of mild or moderate severity, was significantly higher in patients than in controls (aortic valve, 15.4% vs 2.6%; P < .01; mitral valve, 47.2% vs 15.7%; P < .001). Mitral valve prolapse was also more frequent in the patients (5.4%) than in controls (3.9%), but this difference was not statistically significant.CO and cardiac index (CI) were significantly higher in patients than in controls (CO, 9.34 ± 2.28 L/min vs 6.39 ± 1.44 L/min; P < .001; CI, 5.45 ± 0.33 L/min · m2 vs 3.82 ± 0.80 L/min · m2; P < .001), and so were the indexes of cardiac dimensions and LVMass (P < .001). LV fraction shortening and ejection fraction were normal in all patients, ranging above 0.30 and 0.55, respectively, even in patients with CHF. Regarding the LV diastolic function indices, E and A were significantly higher in patients (P < .001) and were compatible with high output state; E-to-A ratio, DT, and IVRT did not differ statistically between patients and controls. Individual patient analyses revealed that 5 patients without CHF had impaired LV relaxation pattern, expressed as E-to-A ratio less than 1, and prolonged deceleration time. The presence of pulmonary hypertension (PHT) in the patient group was
indicated by Doppler indices of pulmonary artery flow and by peak
systolic tricuspid pressure gradient, measured in all patients. PAT and
PAT/RVET were significantly lower in patients than in controls
(111 ± 22 msec vs 127 ± 27 msec, P < .001, and 0.37 ± 0.06 vs 0.42 ± 0.06, P < .05, respectively).
Seventy-one (64.5%) patients had PAT values lower than 120 msec,
indicating increased pulmonary artery pressure.16
Accordingly, total PVR was also significantly higher in patients with
TI (451 ± 294 dyn/sec · cm
In multivariate regression analysis for the entire sample, TG correlated positively with age (P < .001; Figure 3) and cardiac output (P < .001). Total PVR also correlated with age (P < .001). Although TG was significantly higher in patients who underwent splenectomy (P < .05), this relationship became weaker (P > .05) in multivariate analysis because of the confounding effect of age. TG and total PVR failed to show any correlation with left atrial and LV dimensions, hemoglobin level, transfusion therapy, total number of blood units received, serum ferritin level, peak ferritin level, or history of smoking. Patients who had not received transfusions or who had received minimal transfusions (group A) had significantly lower hemoglobin concentrations than those who had received transfusions (group B) (8.8 ± 1.2 g/dL vs 9.3 ± 1.0 g/dL, P < .05, during the 2-year period preceding the study). Accordingly, CO levels were significantly higher in group A (10.01 ± 2.31 L/min vs 8.61 ± 2.02 L/min; P = .001). Patients in group A had higher pulmonary artery pressure levels (TG, 33.63 ± 15.78 mm Hg vs 32.59 ± 11.89 mm Hg), and they were older (34.0 ± 13.0 years vs 30.7 ± 9.0 years), but neither of these differences was statistically significant (P > .05). Serum ferritin concentrations were significantly higher in group B (2088 ± 1386 ng/mL vs 1144 ± 1431 ng/mL in group A; P < .01). Mean peak ferritin levels were 1526 ± 578 ng/mL in group A and 3900 ± 1662 ng/mL in group B (P < .001). Mean patient ages were 27.1 ± 10.4 and 20.3 ± 7.3 years, respectively; (P < .05). Cardiac catheterization Right cardiac catheterization (Table 1) was performed in the 6 patients with CHF; none of them had been previously studied. The presence of PHT and high output state was confirmed. In addition, PVR was increased in all 6 patients, whereas capillary wedge pressure proved normal. Arterial blood gas determinations revealed variable degrees of hypoxemia, but there was no right ventricular oxygen step-up.
Thalassemia intermedia is a heterogeneous disease, in terms of
both clinical manifestations and underlying molecular defects. Several
different genotypes Little is known about cardiac involvement in TI. Our sample of 110 patients, none of whom had a transfusion before the age of 5 or was subjected to a hypertransfusion regimen, showed the above characteristic findings of chronic anemia. Radiographic signs of increased erythropoiesis were frequent and splenomegaly was universal, necessitating splenectomy in most. Cardiac manifestations included rhythm disorders, pericardial and valvular abnormalities, and cardiomegaly. The most prominent findings, however, reflected in electrocardiogram (ECG), radiographs, and echo abnormalities, were PHT and high CO. Six patients with clinical signs of CHF also had as a cause PHT that was confirmed by catheterization. Pericardial and valvular disorders Pericarditis, a well-known cardiac complication of TM,21 was also present in 8.1% of our patients with TI, occurring at a mean patient age of 25.7 ± 14.4 years. Chronic evolutionary pericardial changes were furthermore detected by echocardiography, even in patients without histories of pericarditis. These changes included small-to- moderate pericardial effusion and pericardial thickening. However, the limitations of echocardiography to evaluate this particular disorder must be kept in mind.22 Pericardial calcification, not yet reported in thalassemia, was also noted, probably attributed to the longer lifespans of TI patients. The pathogenesis of pericarditis in these patients was unclear; a likely cause was increased susceptibility to viral infection given the anemia, iron overload, and splenectomy levels in this group. Hemodynamic effects of pericardial involvement in -thalassemia could
be confounded with those of myocardial restriction because of iron
overload, but this is not as heavy in TI as it is in TM.
Valvular lesions are also hard to characterize and to grade with
precision by means of echocardiography. Leaflet thickening and
endocardial calcification, followed often by valvular regurgitation and
occasionally by moderate aortic stenosis, were nevertheless pronounced
in our sample. These modifications were probably caused by the volume
overload and the resultant cardiac dilatation. All of them, on the
other hand, have been related in the literature to pseudoxanthoma
elasticum (PXE).23 A diffuse elastic tissue disorder that
resembles PXE has been described in sickling syndromes and
Pulmonary hypertension Pulmonary hypertension, reported previously in a small sample of 7 patients with TI,4 was the main cardiac finding in the current systematic study. PHT develops as patients grow older, leads to right ventricular deterioration, and is the main cause of CHF. Present in groups A and B in the absence of regular transfusions, PHT was probably related primarily to the consequences of TI rather than to transfusion-associated events such as iron overload. Tissue hypoxia, inevitable in patients who undergo delayed or infrequent blood transfusions, seems to play the central role in the development of PHT in TI. Hypoxia-induced compensatory reactions, which accumulate gradually with age, finally lead to high CO and increased PVR, both characteristic of the patients described here.Cardiac output The degree of pulmonary hypertension, expressed by increased TG, correlated strongly with CO levels. The high output state in TI results not only from chronic anemia but also from the usual presence of hemoglobin F, which impairs oxygen delivery and thereby enhances tissue hypoxia. This, in turn, increases intramedullary and extramedullary erythropoiesis, leading to shunt development that augments gradually with age and raises CO substantially.33 Thus, for a given level of pulmonary vascular resistance, any CO elevation aggravates PHT.Pulmonary vascular resistance The increased PVR found in TI has a multifactorial origin. Besides the mechanical damage of pulmonary vascular endothelium caused by the high CO, increased PVR may also result from lung injury caused by recurrent respiratory tract infections, chest wall deformities, and extramedullary intrapulmonary hemopoietic masses and by age-related diffuse elastic tissue disorders found in TI.24 In this study, TG and PVR failed to show any correlation with serum ferritin concentration or transfusion therapy. This negative result, however, is not conclusive. Serum ferritin levels, despite the differences between groups, stayed universally low, both because transfusions had been delayed and were not as frequent and because chelation therapy was started on time, as soon as ferritin levels started rising. Nevertheless, with advancing age, even moderate levels of iron load may play a role, resulting in interstitial pulmonary fibrosis34 and increased PVR.Particularly in patients with TI, acquired defects of erythrocyte
membrane phospholipids have been noticed,35 leading to hypercoagulability that improved after the initiation of
hypertransfusions.36 This hypercoagulable state is
clinically manifested by a wide spectrum of thromboembolic
events.37 On autopsy, extensive thromboembolic lesions
were found in the pulmonary arterioles of patients with thalassemia who
underwent splenectomy,38 which emphasizes the consequences
of splenectomy on pulmonary vessels. Pulmonary involvement and
respiratory dysfunction with subsequent hypoxemia Left ventricular function It is important to stress that LV function, as estimated by echo-Doppler findings and catheterization data, was normal in our TI sample. This is in contrast to findings in TM, in which LV dysfunction is the main cardiac finding,3 and to findings of reports attributing PHT in hyperkinetic states to LV inability to cope with volume overload.41 Ejection fraction was normal in all patients. There was no pseudonormalization because no correlation was found between Doppler indices of pulmonary artery pressure and left cardiac size, whereas the catheterization measurement showed a normal capillary wedge pressure in patients with CHF. Of course, under certain conditions such as physical exercise, febrile status, or significant anemia aggravation, transient LV dysfunction may be followed by left atrial pressure elevation.Therapeutic considerations In TM, timely and intensive transfusion-iron chelation therapy aims at pretransfusional hemoglobin concentrations of 10 g/dL or more, thereby minimizing hypoxia. This therapeutic strategy, however, has been routinely adopted only in recent years and is not always followed even today. Thus, many patients with thalassemia, especially older ones, have been exposed to the multiple effects of chronic anemia, which, consistent with our analysis, may explain the reported development of PHT in some patients with TM.42Therapeutic strategies in TI, on the other hand, are still a matter of considerable controversy. Several different criteria concerning severe potential complications, are used to decide the initiation of transfusion-chelation therapy.1 We believe that Doppler-determined pulmonary arterial pressure might be added to this list of criteria. In patients with severe PHT, in addition to the standard cardioactive medications, therapy should be aimed at keeping hemoglobin concentrations close to normal. Besides preventing hypoxia-related complications, transfusions also improve coagulation defects.36 In patients with thrombocytosis and a large number of circulating erythroblasts after splenectomy, the administration of hydroxyurea might be helpful. Hydroxyurea has been used in TI to enhance hemoglobin F synthesis,43 whereas an additional benefit in patients with PHT would be the restriction of thrombocytosis and the reduction of circulating myeloid elements. The use of antiplatelet agents has also been proposed for patients who have thalassemia with thrombocytosis and hypoxemia, but it could be dangerous for patients with PXE-like lesions, which predispose to hemorrhagic disorders. In fact, intracranial hemorrhages have been reported in patients with thalassemia who have such lesions.44 Finally, patients with TI after intensive hyper-transfusion-chelation therapy from an early age run a higher risk for cardiomyopathy and left-sided cardiac dysfunction and failure.
Submitted May 10, 2000; accepted February 6, 2001.
The publication costs of this article were defrayed in part by page charge payment. Therefore, and solely to indicate this fact, this article is hereby marked "advertisement" in accordance with 18 U.S.C. section 1734.
Reprints: Athanasios Aessopos, First Department of Internal Medicine, University of Athens School of Medicine, Laiko General Hospital, 17 Aghiou Thoma St, Athens 115 27, Greece.
1. Modell B, Berdoukas V. The Clinical Approach to Thalassemia. New York, NY: Grune & Stratton; 1984. 2. Zurlo MG, De Stefano P, Borgna-Pignatti C. Survival and causes of death in thalassaemia major. Lancet. 1989;2:27-30[Medline] [Order article via Infotrieve]. 3. Ehlers KH, Levin AR, Markenson AL, et al. Longitudinal study of cardiac function in thalassemia major. Ann N Y Acad Sci. 1980;344:397-404[Medline] [Order article via Infotrieve].
4.
Aessopos A, Stamatelos G, Skoumas V, Vassilopoulos G, Mantzourani M, Loucopoulos D.
Pulmonary hypertension and right heart failure in patients with 5. Klinkhoff AV, Thompson CR, Reid GD, Tomlinson CW. M-mode and two-dimensional echocardiographic abnormalities in systemic lupus erythematosus. JAMA. 1985;253:3273-3277[Abstract]. 6. Feigenbaum H. Pericardial disease. In: Feigenbaum H, ed. Echocardiography. 5th ed. Philadelphia, PA: Lea & Febiger; 1994:556-561.
7.
Helmcke F, Nanda NC, Hsiung MC, et al.
Color Doppler assessment of mitral regurgitation with orthogonal planes.
Circulation.
1987;75:175-183 8. Perry GJ, Helmcke F, Nanda NC, Byard C, Soto B. Evaluation of aortic insufficiency by Doppler color flow mapping. J Am Coll Cardiol. 1992;19:1516-1521[Abstract]. 9. Levine RA, Stathogiannis E, Newell JB, Harrigan P, Weyman AE. Reconsideration of echocardiographic standards for mitral valve prolapse: lack of association between leaflet displacement isolated to the apical four-chamber view and independent echocardiographic evidence of abnormality. J Am Coll Cardiol. 1988;11:1010-1019[Abstract].
10.
Sahn DJ, De Maria A, Kisslo J, Weyman A.
The committee on M-mode standardization of the American Society of Echocardiography: results of a survey of echocardiographic measurements.
Circulation.
1978;58:1072-1083 11. Feigenbaum H. Echocardiographic evaluation of cardiac chambers. In: Feigenbaum H, ed. Echocardiography. 5th ed. Philadelphia, PA: Lea & Febiger; 1994:134-173. 12. Devereux RB, Alonso DR, Lutas EM, et al. Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings. Am J Cardiol. 1986;57:450-458[CrossRef][Medline] [Order article via Infotrieve]. 13. Schiller NB, Shah PM, Crawford M, et al. Recommendations for quantitation of the left ventricle by two-dimensional echocardiography: American Society of Echocardiography Committee on Standards Subcommittee. J Am Soc Echocardiogr. 1989;2:358-367[Medline] [Order article via Infotrieve]. 14. Cohen GI, Pietrolungo JF, Thomas JD, Klein AL. A practical guide to assessment of ventricular diastolic function using Doppler echocardiography. J Am Coll Cardiol. 1996;27:1753-1760[Abstract].
15.
Andren B, Lind L, Hedenstierna G, Lithell H.
Left ventricular hypertrophy and geometry in a population sample of elderly males.
Eur Heart J.
1996;17:1800-1807 16. Dabestani A, Mahan G, Gardin J, et al. Evaluation of pulmonary artery pressure and resistance by pulsed Doppler echocardiography. Am J Cardiol. 1987;59:662-668[CrossRef][Medline] [Order article via Infotrieve]. 17. Chan KL, Currie PJ, Seward JB, Hagler DJ, Mair DD, Tajik AJ. Comparison of three Doppler ultrasound methods in the prediction of pulmonary artery disease. J Am Coll Cardiol. 1987;9:549-554[Abstract]. 18. Schillaci G, Verdecchia P, Borgioni C, et al. Improved electrocardiographic diagnosis of left ventricular hypertrophy. Am J Cardiol. 1994;74:714-719[CrossRef][Medline] [Order article via Infotrieve]. 19. Aessopos A, Farmakis D, Taktikou H, Loukopoulos D. Doppler-determined peak systolic tricuspid pressure gradient in persons with normal pulmonary function and tricuspid regurgitation. J Am Soc Echocardiogr. 2000;13:645-649[CrossRef][Medline] [Order article via Infotrieve]. 20. Kanavakis E, Traeger-Synodinos J, Tzetis M, Metaxotou-Mavromati A, Ladis V, Kattamis C. Molecular characterization of homozygous (high HbA2) beta-thalassemia intermedia in Greece. Pediatr Hematol Oncol. 1995;12:37-45[Medline] [Order article via Infotrieve].
21.
Engle MA, Erlandson M, Smith CH.
Late cardiac complications of chronic, severe refractory anemia with hemochromatosis.
Circulation.
1964;30:698-705 22. Isner JM, Carter BL, Bankoff MS, Konstam MA, Salem DN. Computed tomography in the diagnosis of pericardial heart disease. Ann Intern Med. 1982;97:473-479.
23.
Challenor VF, Conway N, Monro JL.
The surgical treatment of restrictive cardiomyopathy in pseudoxanthoma elasticum.
Br Heart J.
1988;59:266-269 24. Aessopos A, Samarkos M, Voskaridou E, et al. Arterial calcifications in beta-thalassemia. Angiology. 1998;49:137-143. 25. Aessopos A, Savvides P, Stamatelos G, et al. Pseudoxanthoma elasticum-like skin lesions and angioid streaks in beta-thalassemia. Am J Hematol. 1992;41:159-164[Medline] [Order article via Infotrieve]. 26. Aessopos A, Voskaridou E, Kavouklis E, et al. Angioid streaks in sickle-thalassemia. Am J Ophthalmol. 1994;117:589-592[Medline] [Order article via Infotrieve]. 27. Tsomi K, Karagiorga-Lagana M, Fragodimitri C, Karabatsos F, Katsiki V. Arterial elastorrhexis: manifestation of a generalized connective tissue disorder in beta-thalassemia major. Eur J Haematol. 1999;63:287-294[Medline] [Order article via Infotrieve]. 28. Lebwohl MG, Distefano D, Prioleau PG, Uram M, Yannuzzi LA, Fleischmajer R. Pseudoxanthoma elasticum and mitral valve prolapse. N Engl J Med. 1982;307:228-231[Medline] [Order article via Infotrieve].
29.
Jessup M, Manno CS.
Diagnosis and management of iron-induced heart disease in Cooley's anemia.
Ann N Y Acad Sci.
1998;850:242-250 30. Lippman SM, Ginzton LE, Thigpen T, Tanaka KR, Laks MM. Mitral valve prolapse in sickle cell disease: presumptive evidence for a linked connective tissue disorder. Arch Intern Med. 1985;145:435-438[Abstract]. 31. Simmons BE, Santhanam V, Castaner A, Rao KR, Sachdev N, Cooper R. Sickle cell heart disease: two-dimensional and Doppler ultrasonographic findings in the hearts of adult patients with sickle cell anemia. Arch Intern Med. 1988;148:1526-1528[Abstract].
32.
Freed LA, Levy D, Levine RA, et al.
Prevalence and clinical outcome of mitral-valve prolapse.
N Engl J Med.
1999;341:1-7 33. Garnet ES, Goddard BA, Markby D, Webber CE. The spleen as an arteriovenous shunt. Lancet. 1969;1:386-388[CrossRef][Medline] [Order article via Infotrieve]. 34. Soergel KH, Sommers SC. Idiopathic pulmonary hemosiderosis and related syndromes. Am J Med. 1962;32:499-511[CrossRef]. 35. Cappellini MD, Coppola R, Robbiolo L, et al. Procoagulant activity of erythrocytes in thalassemia intermedia [abstract]. Blood. 1996;88(suppl 1):38. 36. O'Driscoll A, Mackie IJ, Porter JB, Machin SJ. Low plasma heparin cofactor II levels in thalassaemia syndromes are corrected by chronic blood transfusion. Br J Haematol. 1995;90:65-70[Medline] [Order article via Infotrieve]. 37. Borgna-Pignatti C, Carnelli V, Caruso V, et al. Thromboembolic event in beta thalassemia major: an Italian multicenter study. Acta Haematol. 1998;99:76-79[CrossRef][Medline] [Order article via Infotrieve]. 38. Sonakul D, Fucharoen S. Pulmonary thromboembolism in thalassemic patients. Southeast Asian J Trop Med Public Health. 1992;23(suppl 2):25-28.
39.
Grisaru D, Rachmilewitz E, Mosseri M, et al.
Cardiopulmonary assessment in beta-thalassemia major.
Chest.
1990;98:1138-1142 40. Factor JM, Pottipati SR, Rappoport I, Rosner IK, Lesser ML, Giardina PJ. Pulmonary function abnormalities in thalassemia major and the role of iron overload. Am J Respir Crit Care Med. 1994;149:1570-1574[Abstract]. 41. Okura H, Takatsu Y. High-output heart failure as a cause of pulmonary hypertension. Intern Med. 1994;33:363-365[Medline] [Order article via Infotrieve]. 42. Du ZD, Roguin N, Milgram E, Saab K, Koren A. Pulmonary hypertension in patients with thalassemia major. Am Heart J. 1997;134:532-537[CrossRef][Medline] [Order article via Infotrieve]. 43. Hajjar FM, Pearson HA. Pharmacologic treatment of thalassemia intermedia with hydroxyurea. J Pediatr. 1994;125:490-492[CrossRef][Medline] [Order article via Infotrieve].
44.
Aessopos A, Farmakis D, Karagiorga M, Rombos I, Loucopoulos D.
Pseudoxanthoma elasticum lesions and cardiac complications as contributing factors for strokes in beta-thalassemia patients.
Stroke.
1997;28:2421-2424
© 2001 by The American Society of Hematology.
| ||||||||||
 |
|
 |
|
  F. D. Pashankar, J. Carbonella, A. Bazzy-Asaad, and A. Friedman Prevalence and Risk Factors of Elevated Pulmonary Artery Pressures in Children With Sickle Cell Disease Pediatrics, April 1, 2008; 121(4): 777 - 782. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Anthi, R. F. Machado, M. L. Jison, A. M. Taveira-DaSilva, L. J. Rubin, L. Hunter, C. J. Hunter, W. Coles, J. Nichols, N. A. Avila, et al. Hemodynamic and Functional Assessment of Patients with Sickle Cell Disease and Pulmonary Hypertension Am. J. Respir. Crit. Care Med., June 15, 2007; 175(12): 1272 - 1279. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Voskaridou, G. Tsetsos, A. Tsoutsias, E. Spyropoulou, D. Christoulas, and E. Terpos Pulmonary hypertension in patients with sickle cell/{beta} thalassemia: incidence and correlation with serum N-terminal pro-brain natriuretic peptide concentrations Haematologica, June 1, 2007; 92(6): 738 - 743. [Abstract] [Full Text] [PDF]
|
|
Top
Abstract
Introduction
thalassemia major (TM) and thalassemia intermedia (TI)
5 vs 245 ± 93
dyn/sec · cm