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CORRESPONDENCE We read with interest the recent paper by Nosslinger et
al1 comparing the French-American-British (FAB) and the
World Health Organization (WHO) classifications on 431 unselected
patients with myelodysplastic syndromes (MDS). We were particularly
interested in their analysis of patients (n = 91) with refractory
cytopenia with multilineage dysplasia (RC + Dys), which showed no
significant difference in the median survival when compared to those
(n = 47) with refractory anemia (RA) or refractory anemia with ringed sideroblasts (RARS). We wish to report our experience (in a tertiary referral center) in patients with RA or RARS, classified according to
the extent of dysplasia (ie, single- vs multilineage dysplasia). We have studied 88 consecutive MDS patients with RA or RARS between
January 1992 and January 1999. Clinical details and survival data were
reviewed; bone marrow aspiration slides were examined and classified
according to the WHO criteria for lineage dysplasia. Twenty-four
patients were excluded from the study because of insufficient clinical
information on survival (n = 20), death occurring within 4 weeks of
diagnosis (n = 3), or treatment with bone marrow transplantation (n = 1). The median age of patients with RA/RARS and single-lineage dysplasia
was 74.7 years; median age of patients with bi- or trilineage dysplasia
was 76 years. All but one patient (who had dysthrombopoiesis) in the
single dysplasia groups had erythroid dysplasia. In the RA group, patients with single-lineage dysplasia had a
median survival of 32.8 months (range, 3-96 months) compared to 14.2 months (range, 3-53 months) in patients with multilineage dysplasia;
the difference was significant (P < .05). Similarly, differences in survival were evident in the RARS groups with a median
survival of 40.6 months (range, 2-85 months) in those with single-lineage dysplasia compared to 18.8 months (range, 3-69 months)
in those with multilineage dysplasia. These results did not reach
statistical significance. However, when we combined RA and RARS
patients, we observed highly significant differences in survival times
between those with single-lineage dysplasia (median survival [MS]
36.3 months) and those with multilineage dysplasia (MS 14.9 months). At the time of analysis, 59% (20/34) of patients with
single-lineage dysplasia were alive, but only 10% (3/30) of patients
with multilineage dysplasia were alive. Cytogenetic studies showed abnormalities in 26% of all patients,
but only 16% (8 patients) had results that conferred a worse prognosis
("intermediate risk" = 3, "poor risk" = 5).2
The majority of patients with adverse-risk cytogenetics had
multilineage dysplasia (7/8). There was, as expected, a major
difference in median survival between the 2 groups (30.5 months vs 7.9 months). We did not find cytopenias predictive of the presence of multilineage
dysplasia, nor did we find a difference in survival between those with
2 or 3 cytopenias (24.8 months) and those without (26.2 months). The International Prognostic Scoring System (IPSS)
stratification3 of the 64 patients were as follows:
"low-risk" = 26; "intermediate 1 (INT-1) risk" = 20; and
"INT-2 risk" = 3. The IPSS could not be applied to 15 patients
because of a lack of cytogenetics. Table 1 shows the relationship of median
survival to various prognostic scoring systems in combined RA and RARS
groups. Overall, combining the IPSS with lineage dysplasia had greater
prognostic power than IPSS alone in these so-called good-risk FAB
subtypes. Our findings are similar to those reported by Rosati et
al4 and Matsuda et al,5 supporting the WHO
classification of MDS and justifying the identification of patients
with multilineage dysplasia in the RC + Dys subgroup.
Scott M. Dunkley, Arumugam Manoharan, and Yiu Lam Kwan
References
1.
Nosslinger T, Reisner R, Koller E, et al.
Myelodysplastic syndromes, from French-American-British to World Health Organization: comparison of classifications on 431 unselected patients from a single institution.
Blood.
2001;98:2935-2941 2. Fenaux P, Morel P, Lai JL. Cytogenetics of myelodysplastic syndromes. Semin Hematol. 1996;33:127-138[Medline] [Order article via Infotrieve].
3.
Greenberg P, Cox C, Le Beau MM, et al.
International scoring system for evaluating prognosis in myelodysplastic syndromes.
Blood.
1997;89:2079-2088 4. Rosati S, Mick R, Xu F, et al. Refractory cytopenia with multi-lineage dysplasia: further characterization of an unclassifiable myelodysplastic syndrome. Leukemia. 1996;10:20-26[Medline] [Order article via Infotrieve]. 5. Matsuda A, Jinnai F, Yagasaki S, et al. Refractory anaemia with severe dysplasia: clinical significance of morphological features in refractory anaemia. Leukemia. 1998;12:482-485[CrossRef][Medline] [Order article via Infotrieve].
Response:Controversy in MDS classificationWe read with interest the letter to the editor entitled "Myelodysplastic syndromes: prognostic significance of multilineage dysplasia in patients with refractory anemia or refractory anemia with ringed sideroblasts" by Dunkley et al presenting their data from myelodysplastic syndrome (MDS) patients with less than 5% medullary blasts classified according to the World Health Organization (WHO) classification.1 Although some published data provides evidence that presence of dysplastic features in 2 or 3 cell lineages has a negative impact on the survival duration of MDS patients with less than 5% medullary blasts at the time of diagnosis,2-4 our own data from 189 MDS patients without excess of blasts cannot support this hypothesis.5 As published data are inconsistent, Dunkley et al's letter addresses an important problem concerning definition, classification, and prognosis of early stage myelodysplastic syndromes. The study population of 64 patients presented by the authors is quite small. As this cohort is divided into 4 subgroups (15-20 patients in each subgroup; the exact number is not mentioned in the text), the explanatory strength of the (significant) results of Dunkley et al is not entirely convincing. It remains to be investigated whether the prognostic value persists when the comparison is controlled for other aspects (eg, the IPSS). Also the generalizability of the results is unclear. Furthermore, the median survival times of the 2 small subgroups RA and RARS with single-lineage dysplasia of 32.8 and 40.6 months, respectively, are quite short compared to the majority of published data.4-7 The median survival durations of these MDS entities are usually around 55 to 60 months, even if the patients are classified according to the French-American-British (FAB) criteria. Similarly, the median survival durations of the small subgroups RA and RARS with multilineage dysplasia of 14.2 and 18.8 months, respectively, are short. It should be noted that these patients still present with less than 5% blast cells in the bone marrow at the time of diagnosis. We agree that as mentioned by the authors adverse-risk cytogenetics (according to the IPSS) in MDS patients correlate with bad prognosis and shorter survival.6-9 Moreover, the authors discuss that multilineage dysplastic features correlate with severe cytogenetic abnormalities. To our knowledge, no paper has been published supporting this hypothesis in MDS. Nevertheless, this is an important issue that cannot be adequately addressed by this letter because of the small patient cohort. As recently discussed at the last American Society of Hematology meeting, the exact definition of dysplasia, especially the percentage of dysplastic cells in each lineage, seems to be of importance. We would therefore be interested in the threshold fixed by Dunkley et al for definition of presence of dysplasia in the 3 different cell lineages. In conclusion the authors raise important questions concerning classification, prognosis, and consequently treatment requirement in patients with early stage MDS. These cannot be answered because of the low patient number in this study. Because of the heterogeneous nature of MDS, larger studies are warranted in order to reach answers to these questions.
Thomas Nösslinger, Regina Reisner, Heinz Tüchler, Elisabeth Pittermann, and Michael Pfeilstöcker
References
1.
Harris NL, Jaffe ES, Diebold J, et al.
World Health Organization of neoplastic diseases of the hematopoietic and lymphoid tissues: report of the clinical advisory committee meeting 2. Rosati S, Mick R, Xu F, et al. Refractory cytopenia with multilineage dysplasia: further characterization of an `unclassifiable' myelodysplastic syndrome. Leukemia. 1996;10:20-26. 3. Matsuda A, Jinnai I, Yagasaki F, et al. Refractory anemia with severe dysplasia: clinical significance of morphological features in refractory anemia. Leukemia. 1998;12:482-485. 4. Germing U, Gattermann N, Strupp C, Aivado M, Aul C. Validation of the WHO proposals for a new classification of primary myelodysplastic syndromes: a retrospective analysis of 1600 patients. Leuk Res. 2000;24:983-992[CrossRef][Medline] [Order article via Infotrieve]. 5. Nösslinger T, Reisner R, Koller E, et al. Myelodysplastic syndromes, from French-American-British to World Health Organization: comparison of classifications on 431 unselected patients from a single institution. Blood. 2001;98:2935-2941. 6. Greenberg P, Cox C, LeBeau MM, et al. International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood. 1997;89:2079-2088. 7. Morel P, Hebbar M, Lai JL, et al. Cytogenetic analysis has strong prognostic value in de novo myelodysplastic syndromes and can be incorporated in a new scoring system: a report on 408 cases. Leukemia. 1993;7:1315-1323[Medline] [Order article via Infotrieve]. 8. Jotterand M, Parlier V. Diagnostic and prognostic significance of cytogenetics in adult primary myelodysplastic syndromes. Leuk Lymphoma. 1996;23:253-266[Medline] [Order article via Infotrieve]. 9. Sole F, Espinet B, Sanz GF, et al. Incidence, characterization and prognostic significance of chromosomal abnormalities in 640 patients with primary myelodysplastic syndromes: Grupo Cooperativo Espanol de Citogenetica Hematologica. Br J Haematol. 2000;108:346-356[CrossRef][Medline] [Order article via Infotrieve].   CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
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Airlie House, Virginia, November 1997.
J Clin Oncol.
1999;17:3835-3849
