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Figure 1.
RH locus in human and mouse.
The human RH locus (top) is compared to the mouse
RH locus (bottom). The orientations and positions of genes
are indicated by gray arrows, the rhesus boxes by white triangles. The
fragment of the mouse RH gene shown covers exons 2 to 10. An
open reading frame (ORF) in the rhesus box is depicted as a black
circle, the succinate dehydrogenase complex, subunit D precursor
pseudogene in RH intron 3 as a white circle; no sequences
homologous to these ORF were found in the mouse locus. During the
duplication event, RHD and its fringing rhesus boxes were
inserted between NPD014 and SMP1. The depicted
DNA segments are GCIP-binding protein P29 (accession numbers
human, NM_015484; mouse, AY033432), NPD014 (AF247168,
AK003799), SMP1 (NM_014313, AK014282) and RH(CE)
(M34015, NM_011270), and the ORF in the upstream and downstream rhesus
boxes (XP_044740 and XP_057505).
