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Blood, Vol. 109, Issue 8, 3567-3569, April 15, 2007 This Article Abstract Full Text Services Email this article to a friend Alert me to new issues of the journal Rights and Permissions Citing Articles Citing Articles via CrossRef Abcb7, the gene responsible for X-linked sideroblastic anemia with ataxia, is essential for hematopoiesis Blood Pondarre et al. 109: 3567 Supplemental materials for: Pondarre et al, Vol 109, Issue 8, 3567-3569 Files in this Data Supplement: Figure S1. Abcb7fl allele rearrangement in Abcb7fl+Mx1-Cre tissues (JPG, 29 KB) - Conditional allele (fl) and null allele (–) from a male Abc7fl/fl+Mx1-Cre animal treated with pI-pC killed on day 17 after induction. Note essentially complete deletion in bone marrow and liver and absence of deletion in brain and testis. Figure S2. Transient siderocytosis following Mx1-Cre–mediated Abcb7 gene deletion (JPG, 43.8 KB) - Serial peripheral blood siderocyte count in 5 representative Abcb7fl + Mx1-Cre animals induced at 4 weeks of age. Figure S3. Abcb7 is essential for hematopoiesis in weanling animals (JPG, 34.5 KB) - (A) Survival curve of 4-week-old Abc7fl+/–Mx1-Cre animals induced with pI-pC. (■) –Cre, (◆) +Cre. (B) Peripheral blood parameters of animals immediately before death. Values represent the mutant value expressed as a percentage of the control value. Hb indicates hemoglobin; Retic; absolute reticulocyte count; WBC, white blood cells; PLT, platelets. This Article Abstract Full Text Services Email this article to a friend Alert me to new issues of the journal Rights and Permissions Citing Articles Citing Articles via CrossRef

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