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Blood, Vol. 109, Issue 9, 3812-3819, May 1, 2007 This Article Abstract Full Text Services Email this article to a friend Alert me to new issues of the journal Rights and Permissions Citing Articles Citing Articles via CrossRef Inhibitory effect of tumor cell–derived lactic acid on human T cells Blood Fischer et al. 109: 3812 Supplemental materials for: Fischer et al, Vol 109, Issue 9, 3812-3819 Files in this Data Supplement: Figure S1. Schematic illustration of T-cell suppression by external lactic acid (PDF, 21.8 KB) - During activation, T cells metabolize glucose to lactate, which is transported out through MCT-1; high extracellular concentrations of lactic acid hamper continuous lactate efflux and thereby suppress glycolysis and activation in human T cells. This Article Abstract Full Text Services Email this article to a friend Alert me to new issues of the journal Rights and Permissions Citing Articles Citing Articles via CrossRef

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