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Blood, Vol. 109, Issue 5, 1897-1907, March 1, 2007
Retroviral vector insertion sites associated with dominant hematopoietic clones mark "stemness" pathways
Blood Kustikova et al.
109: 1897
Supplemental materials for: Kustikova et al, Vol 109, Issue 5, 1897-1907
Files in this Data Supplement:
- Document S1. Supplemental materials and methods (PDF, 64 KB)
- Table S1. Insertion sites listed in the IDDb (PDF, 121 KB) -
Insertion coordinates are given based on the NCBI database, July 2004–October 2006. RTCGD membership is given based on the database’s information accessible between July 2004 and January 2006. NA indicates not applicable; TSS, transcriptional start site; AML, acute myeloid leukemia; EL, erythroid leukemia; HS, histiocytic sarcoma; LL, lymphatic leukemia; MPD-ML, myeloproliferative disease–like myeloid leukemia; MDS, myelodysplastic syndrome. * indicates location in gene-dense region; †, insertions published by Modlich et al1; ‡, insertions published by Kustikova et al2; §, insertion published by Li et al3; ¶, insertion sites of dominant clones identified by LAM-PCR. Some of the previously published insertions have also been updated in terms of genomic location. Gene names in brackets indicate previous nomenclature data according to NCBI as of July 2004. In some cases for hits located more than 10 kb from TSS, the distance is given in kilobases.
- Table S2. Ingenuity analysis of IDDb genes (PDF, 640 KB) -
(A) Ingenuity analysis of all IDDb genes. (B) Ingenuity analysis of IDDb genes listed in Table 2.
- Table S3. Ten most relevant network-based pathways (Ingenuity) associated with all IDDb genes (PDF, 10.5 KB) -
REFERENCES
1. Modlich U, Kustikova O, Schmidt M, et al. Leukemias following retroviral transfer of multidrug resistance 1 are driven by combinatorial insertional mutagenesis. Blood. 2005;105:4235-4246.
2. Kustikova OS, Fehse B, Dullmann J, et al. Clonal dominance of hematopoietic stem cells triggered by retroviral gene marking. Science. 2005;308:1171-1174.
3. Li Z, Dullmann J, Schiedlmeier B, et al. Murine leukemia induced by retroviral gene marking. Science. 2002;296:497.
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