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Blood, Vol. 110, Issue 4, 1291-1300, August 15, 2007
Gene-expression profiling identifies distinct subclasses of core binding factor acute myeloid leukemia
Blood Bullinger et al.
110: 1291
Supplemental materials for Bullinger et al, Vol 110, Issue 4, 1291-1300
Files in this Data Supplement:
- Table S1. Filtered CBF leukemia (n = 93) gene expression data set (XLS, 13.4 MB)
- Table S2. Normalized CBF leukemia (n = 58) array CGH data set (XLS, 8.61 MB)
- Table S3. SAM-defined genes discriminating among t(8;21) and inv(16) cases (XLS, 1.65 MB)
- Table S4. GO categories discriminating among t(8;21) and inv(16) cases (XLS, 26.5 KB)
- Table S5. SAM-defined genes discriminating among hierarchical cluster–defined CBF) subgroups (XLS, 1.95 MB)
- Figure S1. Correlation of hierarchical cluster–defined CBF groups with outcome (JPG, 87.4 KB)
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(A) Kaplan–Meier estimates of the cumulative incidence of relapse (CIR) in the two hierarchical cluster–defined core binding factor (CBF) leukemia groups I and II; the difference between groups I and II was not significant (P = .28; log-rank test). (B) Kaplan–Meier estimates of CIR and cumulative incidence of death (CID) for the patients of the CBF leukemia groups I and II that have received chemotherapy as post-remission therapy (patients that have received either autologous or allogeneic stem-cell transplantation have been excluded for this analysis). There was a trend towards a higher incidence of relapse and death in group I (P =.11 and P =.14 for CIR and CID, respectively; log rank test; Figure S1B).
- Figure S2. Parallel analysis of array CGH and GEP (JPG, 151 KB)
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(A) Enlarged view of the array comparative genomic hybridization (CGH) profile of a t(8;21) AML case with del(9)(q21q21). (B) The lost clones are colored in green. (C,D) Correlation of array (C) CGH and (D) gene expression profiling (GEP) findings identifies candidate genes located in the deleted region like, for example, the tyrosine kinase SYK, which has been proposed to be a potent modulator of epithelial cell growth and a potential tumor suppressor in breast carcinomas. Genomic aberrations and gene expression levels are color-coded according to the indicated pseudocolor scale.
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