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Blood, Vol. 110, Issue 1, 323-333, July 1, 2007
A novel fusion of RBM6 to CSF1R in acute megakaryoblastic leukemia
Blood Gu et al.
110: 323
Supplemental materials for: Gu et al, Volume 110, Issue 1, 323-333
Files in this Data Supplement:
- Table S1. Phosphopeptides identified by LC-MS/MS in MKPL-1 cells (XLS, 93 KB)
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‘y’ in peptide indicates phosphorylated tyrosine residue; ‘§’, known phosphorylation site.
- Figure S1. Histopathological analysis of Balb/C mice (JPG, 99.2 KB)
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Hematoxylin and eosin staining of tissue sections showing small infiltrates of myeloid cells in liver and enlargement of the red pulp in the spleen.
- Figure S2. Histopathological analysis of lethal myeloproliferative disease (JPG, 114 KB)
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Hematoxylin and eosin staining of (A) spleen and (B) liver sections. (C) Immunohistochemistry on spleen section using von Willebrand factor antibody. (D) Reticulin fiber staining of spleen section.
- Figure S3. Blood counts from animals that received transplants (JPG, 47 KB)
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(A) White blood cell counts, (B) hematocrit percentages, (C) platelet counts, and (D) liver weights were obtained 150 days after transplantation.
- Figure S4. Subcellular localization of the RBM6-CSF1R fusion protein (JPG, 32.7 KB)
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MKPL-1 cells were fractionated into plasma membrane, cytosol, and nuclei compartments. Immunoblot analysis showed that RBM6-CSF1R is localized in the cytosol. Transferrin receptor, -actin, and lamin A/C were used as markers for plasma membrane, cytosol, and nuclei compartment, respectively. Asterisk indicates a nonspecific band; arrow, RBM6-CSF1R.
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