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Blood, Vol. 110, Issue 2, 709-718, July 15, 2007
JS-K, a GST-activated nitric oxide generator, induces DNA double-strand breaks, activates DNA damage response pathways, and induces apoptosis in vitro and in vivo in human multiple myeloma cells
Blood Kiziltepe et al.
110: 709
Supplemental materials for Kiziltepe et al, Vol. 110, Issue 2, 709-718
Files in this Data Supplement:
- Table S1. Low dose bortezomib sensitizes MM cells to JS-K (PDF, 11.1 KB) -
MM.1S cells were treated with bortezomib (0, 1, 2, 3 nM) for 8 hours, followed by JS-K treatment (0, 0.3, 0.6 µM). Isobologram analysis was done based on MTT assay results (48 hours). Fraction affected (FA) and Combination Index (CI) for each combination are shown.
- Figure S1. Overexpression of GSTM1 and GSTP1 by MM cells (PDF, 100 KB) -
Based on an expression profiling study of primary tumor cells from 67 MM patients and plasma cells from 12 healthy donors, 39% and 33% of the MM cells overexpressed GSTM1 and GSTP1, respectively, compared with the plasma cell (PC) controls. Overexpression is defined as MM cells expressing GSTs ≥ PC (mean + 2 SD).
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