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Blood, Vol. 110, Issue 2, 783-786, July 15, 2007
Absence of donor T-cell–derived soluble TNF decreases graft-versus-host disease without impairing graft-versus-tumor activity
Blood Borsotti et al.
110: 783
Supplemental materials for Borsotti et al, Vol 110, Issue 2, 783-786
Files in this Data Supplement:
- Figure S1. memTNF and wt T cells expansion and phenotype at day 21 after BMT (JPG, 121 KB)
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(A,B) Lethally irradiated (850cGy) BALB/c mice received 5 × 106 TCD wt B6 BM cells in combination with 1 × 106 wt (black dots) or memTNF (gray dots) B6 T cells. Recipient spleens were harvested at day 21 for fluorescent-assisted cell sorting (FACS) analysis of CD44, CD62L, and CD25 expression on donor CD4+ and CD8+ T cells. Scatter dot plots represent the absolute numbers of CD4+ and CD8+ T cells and their subsets, mean (± SEM) for 9 mice per group.
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