SEARCH:   Advanced

Blood, Vol. 110, Issue 7, 2641-2649, October 1, 2007 This Article Abstract Full Text Services Email this article to a friend Alert me to new issues of the journal Rights and Permissions Citing Articles Citing Articles via CrossRef Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cells Blood Davenport et al. 110: 2641 Supplemental materials for Davenport et al, Vol. 110, Issue 7, 2641-2649 Files in this Data Supplement: Figure S1. Treatment with dexamethasone or melphlan does not induce ER stress in myeloma cells (PDF, 23.4 KB) - Treatment of myeloma cells over a 24 hour period with dexamethasone or melphalan failed to induce splicing of XBP1, as demonstrated by RT-PCR (A). Levels of the pro-apoptotic factor CHOP were determined by real-time “Taqman” PCR (B). Representative cell line data on MM1S and U266 is shown. Figure S2. The Hsp90 inhibitor 17-AAG induces ER stress in colon cancer cells (PDF, 19.1 KB) - Treatment of colon cancer cells over a 24 hour period with 17-AAG induced splicing of XBP1, as demonstrated by RT-PCR (A). Levels of the pro-apoptotic factor CHOP were determined by real-time “Taqman” PCR (B). Immunoblotting of nuclear fractions of cell lysates demonstrated an increase in cleaved ATF6. (C). Representative cell line data on HTC116 is shown. This Article Abstract Full Text Services Email this article to a friend Alert me to new issues of the journal Rights and Permissions Citing Articles Citing Articles via CrossRef

	Copyright © 2009 by American Society of Hematology         Online ISSN: 1528-0020