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Blood, Vol. 110, Issue 7, 2708-2717, October 1, 2007
Epinephrine-induced activation of LW-mediated sickle cell adhesion and vaso-occlusion in vivo
Blood Zennadi et al.
110: 2708
Supplemental materials for Zennadi et al, Vol. 110, Issue 7, 2708-2717
Original video segments supporting data presented in Figure 3.
Files in this Data Supplement:
- Video 1. Sham-treated SS RBCs showed very little adhesion (5×) (MOV, 2.95 MB)
- Video 2. Sham-treated SS RBCs showed very little adhesion (20×) (MOV, 4.84 MB)
- Video 3. Treatment of SS RBCs with forskolin and IBMX resulted in increased RBC adhesion with intermittent occlusion of small diameter vessels and permanent blockage of some vessel segments, especially at junctions (5×) (MOV, 4.77 MB)
- Video 4. Treatment of SS RBCs with forskolin and IBMX resulted in increased RBC adhesion with intermittent occlusion of small diameter vessels and permanent blockage of some vessel segments, especially at junctions (20×) (MOV, 4.87 MB)
- Video 5. Epinephrine induced time-dependent adhesion of SS RBCs, 2 minutes after infusion of SS RBCs (MOV, 3.2 MB)
- Video 6. Epinephrine induced time-dependent adhesion of SS RBCs, 27 minutes after infusion of SS RBCs (MOV, 1.31 MB)
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Epinephrine-treated SS RBC infusion also led to the permanent obstruction of small diameter venules.
- Video 7. Adhesion to small vessels after infusion of epinephrine-treated SS RBCs (MOV, 5.18 MB)
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Epinephrine-treated SS RBC infusion also led to the permanent obstruction of small diameter venules.
- Video 8. Adhesion to larger vessels after infusion of epinephrine-treated SS RBCs (MOV, 4.97 MB)
- Video 9. In some large vessels, adhesion of epinephrine-treated SS RBCs caused occasional stoppages in blood flow with reversal of direction (MOV, 3.25 MB)
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