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Blood, Vol. 110, Issue 3, 1064-1072, August 1, 2007
IFN differentially controls the development of idiopathic pneumonia syndrome and GVHD of the gastrointestinal tract
Blood Burman et al.
110: 1064
Supplemental materials for Burman et al, Vol.110, Issue3, 1064-1072
Files in this Data Supplement:
- Figure S1 (PDF, 183 KB) -
(A) Clinical scores in B6D2F1 recipients of T-cell–replete (n=8 per group) or TCD (n=4) IFN R−/− B6 grafts in the presence of TNFR:Fc (to neutralize TNF ) or control IgG from day −2 to day +21, as shown. Data are mean plus or minus SE of scores from each animal. # indicates P<0.001, **, P<0.01, TNFR:Fc vs control IgG allogeneic recipients. (B) Representative immunohistochemical staining for VCAM-1 in lung of wt and IFNR−/− recipients of T-cell-replete allogeneic grafts nine days after BMT (60× magnification). (C) mRNA levels of hemeoxygenase-1 (HOX-1) by real-time PCR in lung of wt and IFNR−/− recipients of T-cell-replete (n=10) and TCD (n=4-6) grafts nine days after BMT. Data expressed as mean plus or minus SE. (D) Chemokine levels determined by ELISA in cell lysates derived from the right upper lobe in wt and IFNR−/− recipients of T-cell–replete (n=4-5) and respective TCD groups (n=2-3) at days 3 and 9 after transplant. Data expressed as mean plus or minus SE.
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