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Blood, Vol. 111, Issue 8, 4297-4308, April 15, 2008
AML1 mutations induced MDS and MDS/AML in a mouse BMT model
Blood Watanabe-Okochi et al.
111: 4297
Supplemental materials for: Watanabe-Okochi et al
Files in this Data Supplement:
- Table S1. Experimental conditions and outcomes of transplanted mice (XLS, 34.5 KB)
- Table S2. Diagnosis and hematologic data of transplanted mice (XLS, 30 KB)
- Table S3. Hematologic data of serial transplanted mice (XLS, 28.5 KB)
- Figure S1. Differentials of bone marrow cells of the transplanted mice (JPG, 56 KB)
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Ery, erythrocyte; Lym, lymphocyte; Mono, monocyte; Neu, neutrophils; Meta, metamyelocyte, and Blast, blast.
- Figure S2. MN1 overexpression in the leukemic cells of mice/S291fs harboring an integration into intron 1 of MN1 (JPG, 30.4 KB)
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Real time PCR for MN1 in bone marrow derived from morbid mice/D171N or mice/S291fs or mice/WT or mice/mock or normal mice. Mice ID 55 and 56 had integration into intron 1 of MN1. RNA from normal bone marrow cells served as a control (RNA level = 1).
- Figure S3. Surface markers of leukemic cells derived from mice/S291fs were different from mice/D171N (JPG, 84.1 KB)
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(A) The dot plots show Ly5.1, Gr-1, CD11b, B220, CD3, CD41, c-kit, Sca-1, CD34, or Ter119 labeled with a corresponding PE-conjugated mAb versus expression of GFP. (B) Leukemic cells derived from mice/S291fs were serially transplantable. The phenotypes of serial transplanted cells were identical in principle with primary leukemic cells.
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