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Blood, Vol. 110, Issue 3, 928-936, August 1, 2007 This Article Abstract Full Text Services Email this article to a friend Alert me to new issues of the journal Rights and Permissions Citing Articles Citing Articles via CrossRef SIV-specific CD8+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection Blood Petrovas et al. 110: 928 Supplemental materials for Petrovas et al, Vol. 110, Issue 3, 928-936 Files in this Data Supplement: Figure S1. MFI levels of PD-1 are significantly higher in CM9-specific CD8+ T cells compared to total CD8+ T cells (JPG, 83.1 KB) - Pooled data showing the levels of PD-1 expressed in terms of mean fluorescence intensity (MFI) for total and CM-9 specific CD8+ T cells isolated from PBMC, spleen, lymph node (LN), and mucosa tissues. The PD-1 levels in memory populations are also shown. The analysis of PD-1 levels for total CD8+ T cell populations from noninfected and SIV- or treated/SIV-challenged animals (gated area) is highlighted in the lower panel. Horizontal lines depict mean values. The P values were calculated using Student t test. Figure S2. Appearance of escape mutations early after infection specifically characterizes the TL8 epitope (JPG, 46.4 KB) - Sequencing analysis of viral RNA was performed and the mutations found are shown for both TL8 and CM9 epitopes at 2 and 8 weeks after infection. Ten (n=3 animals) or 7 (n=1 animal) clones for each epitope were analyzed. The position of the mutated amino acids is also shown. This Article Abstract Full Text Services Email this article to a friend Alert me to new issues of the journal Rights and Permissions Citing Articles Citing Articles via CrossRef

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