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Blood, Vol. 110, Issue 3, 886-893, August 1, 2007
An IAP retrotransposon in the mouse ADAMTS13 gene creates ADAMTS13 variant proteins that are less effective in cleaving von Willebrand factor multimers
Blood Zhou et al.
110: 886
Supplemental materials for Zhou et al, Vol. 110, Issue 3, 886-893
Files in this Data Supplement:
- Table S1. Sequences of oligonucleotides used in this study (PDF, 76.2 KB)
- Table S2. Nucleotide and amino acid sequences (PDF, 21.1 KB) -
(A1) Nucleotide sequence of the IAP-a variant of mouse ADAMTS13 cDNA. This sequence, identical to AB071302 in the NCBI database, is shown here for comparison. The sequence of 180 base pairs not found in the IAP-b variant is underlined. The 3′ untranslated sequence is shaded. (A2) Predicted amino acid sequence of the IAP-a variant of mouse ADAMTS13 (1037 residues): Residues not found in the IAP-b variant are underlined. Residues common to both IAP-a and IAP-b variants but not present in full-length mouse ADAMTS13 are shaded. (B1) Nucleotide sequence of the IAP-b variant form of mouse cDNA. The sequence not found in IAP-a is underlined. The 3′ untranslated sequence is shaded. (B2) Predicted amino acid sequence of IAP-b (1028 residues): Residues not found in IAP-a or full-length mouse ADAMTS13 are underlined. Residues common to both IAP-a and IAP-b variants but not present in full-length mouse ADAMTS13 are shaded.
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