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Blood, Vol. 110, Issue 12, 3968-3977, December 1, 2007
Caspase-cleaved HPK1 induces CD95L-independent activation-induced cell death in T and B lymphocytes
Blood Brenner et al.
110: 3968
Supplemental materials for: Brenner et al
Files in this Data Supplement:
- Figure S1. T cells from gld mice show TCR-induced AICD (JPG, 50.9 KB)
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Primary T cells from gld mice, which express mutated, non-functional CD95L were analyzed at day 5 post stimulation for activation-induced cell death (AICD). Incubation of activated gld T cells with 1 or 10 µg/ml of plate bound anti-CD3 antibodies for 18 h results in cell death (left side, measured by FSC/SSC analysis) and nuclear fragmentation (right side, measured by PI-staining) independent of CD95L. Standard deviation is given for triplicate measurements. The experiment presented is representative of 5 repeats.
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