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Blood, Vol. 110, Issue 8, 3005-3014, October 15, 2007
The molecular signature of MDS stem cells supports a stem-cell origin of 5q– myelodysplastic syndromes
Blood Nilsson et al.
110: 3005
Supplemental materials for Nilsson et al, Vol. 110, Issue 8, 3005-3014.
Files in this Data Supplement:
- Table S1. Genes sorted as up-regulated and down-regulated in normal CD34+CD38−Thy-1+ stem cells, compared to normal CD34+CD38+Thy-1− progenitors (XLS, 701 KB)
- Table S2. Expression of genes located at 5q31-q32 in 5q deleted CD34+CD38−Thy-1+ candidate HSCs (XLS, 18 KB).
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Gene expression profile of genes located at 5q31-q32 from four patients (#1, #2, #3, and #5) with the 5q- syndrome compared to healthy individuals, expressed as Fisher scores for individual genes, and frequency of patients with down-regulated expression when compared to the mean of 5 healthy subjects. TF indicates transcription factor. *Microarray-based expression validated by Q-PCR.
- Table S3. Genes ranked by differential expression in 5q- CD34+CD38−Thy-1+ stem cells, compared to normal CD34+CD38−Thy-1+ stem cells (XLS, 681 KB)
- Figure S1. Differential gene expression in normal CD34+CD38−Lin− and CD34+CD38−Thy-1+ HSCs (JPG, 21.9 KB).
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ROC curves comparing set of genes up-regulated in normal CD34+CD38−Lin− cells6 with our list of genes ranked by up-regulation in normal CD34+CD38−Thy-1+ HSCs (solid line), and the corresponding set of genes reported down-regulated in CD34+CD38−Lin− cells with our reversed ranked list (dashed line). The ROC curves show sensitivity versus 1-specificity, for all possible cut-offs in the ranked list. Dotted line corresponds to random expectation.
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