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Blood, Vol. 111, Issue 2, 776-784, January 15, 2008
Molecular allelokaryotyping of pediatric acute lymphoblastic leukemias by high-resolution single nucleotide polymorphism oligonucleotide genomic microarray
Blood Kawamata et al.
111: 776
Supplemental materials for: Kawamata et al
Files in this Data Supplement:
- Table S1. Correlation of recurrent chromosomal abnormalities in ALL samples (PDF, 29KB) -
Significance of relationships between each non-random genetic abnormality was calculated by Fisher’s correlation coefficients method. Only the relationships that had a p-value less than 0.01 are listed. Gain chr. 21: These cases had gain of whole or long arm of chromosome 21 in non-HD-ALL (283 cases). Gain chr. X: These cases had gain of whole or long arm of chromosome X in non-HD-ALL (283 cases). Dup: duplication, Amp: amplification, Del: deletion, neg.: negative, HD: hyperdiploid ALL (chromosomes > 50). UPD: uniparental disomy.
- Table S2. Primer Sequences (PDF, 22KB)
- Figure S1. Numerical abnormalities detected in 399 childhood ALL cases (PDF, 18KB) -
(A) Numerical abnormalities grouped based on either HD-ALL or non-HD ALL cases.
(B) Trisomy/tetrasomy/pentasomy of chromosome 21. Trisomy 21 was detected in 43 cases of ALL; 21 cases in non-HD-ALL and 23 cases in HD-ALL. Eleven cases showing trisomy 21 in matched controls (possibly Down syndrome patients) are excluded. All pentasomy and tetrasomy except for one case, were HD-ALL
- Figure S2. Chromosomal abnormalities detected in 399 cases of pediatric ALL (PDF, 41KB) -
All chromosomes except chromosomes 9 and 12 are shown. Green lines under the chromosomes indicate the deleted regions in individual cases. Brown lines above the chromosomes indicate the duplicated regions. Rectangles show the commonly deleted or duplicated/amplified regions; possible candidate tumor suppressor genes or oncogenes are also indicated. Green and red bands on idiograms indicate centromeres and non-coding regions, respectively.
- Figure S3. ALL with 9q duplication/amplification detected by SNP-chip (PDF, 19KB) -
(A) Event-free survival of childhood ALL patients with 9q amplification.
Panel B shows the representative pattern of abnormalities detected in 3 cases of B-cell lineage ALL which had duplication of 22p with the duplication of 9q. Panel C shows the representative pattern of abnormalities detected in 2 cases of T-cell lineage ALL. Very high copy number amplification (higher than level 4) in a very small region involving ABL and NUP214 genes.
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