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Blood, Vol. 110, Issue 13, 4436-4444, December 15, 2007 This Article Abstract Full Text Services Email this article to a friend Alert me to new issues of the journal Rights and Permissions Citing Articles Citing Articles via CrossRef Rapid and selective death of leukemia stem and progenitor cells induced by the compound 4-benzyl, 2-methyl, 1,2,4-thiadiazolidine, 3,5 dione (TDZD-8) Blood Guzman et al. 110: 4436 Supplemental materials for: Guzman et al Files in this Data Supplement: Figure S1. TDZD-8 does not induce cell death of primary mononuclear cells from normal specimens (PDF, 103 KB) - Normal (healthy donors) specimens obtained from BM, CB or MPB specimens as indicated were cultured for 18-24 hours in the presence of 20µM TDZD-8. Cell viability was assessed by Annexin V/7AAD staining. Percent viability is represented relative to untreated control. Error bars represent the SEM. Figure S2. TDZD-8 induces cell death in primary lymphoid malignancies with rapid kinetics (PDF, 177 KB) - (A) CLL (n=4) and (B) ALL (n=3) specimens were treated with 20µM TDZD-8 at the indicated time points. Viability was assessed using Annexin V/7AAD stain. To assay phenotypically described stem cells, samples were co-stained and gated for indicated surface antibodies. Error bars represent the SEM. Percent viability is represented relative to untreated control. This Article Abstract Full Text Services Email this article to a friend Alert me to new issues of the journal Rights and Permissions Citing Articles Citing Articles via CrossRef

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