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Blood, Vol. 111, Issue 3, 1534-1542, February 1, 2008
Chromosomal lesions and uniparental disomy detected by SNP arrays in MDS, MDS/MPD, and MDS-derived AML
Blood Gondek et al.
111: 1534
Supplemental materials for: Gondek et al
Files in this Data Supplement:
- Table S1. SNP array finding and clinical data of patients included in the study (XLS, 128 KB)
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Table presents the clinical data and exact location of the lesions found in the patient cohort. WHO classification, metaphase cytogenetics bone marrow morphology, IPSS classification, therapies and outcomes are also included. A Based on Modified International Working Group Criteria; B blasts comprise 11% of all cells and 27% of non-erythroid cells (WHO criteria for secondary AML); C MS NMA PSC− HLA-matched sibling non-myeloablative peripheral stem cell transplant; D MU NMA PSC− HLA-matched unrelated non-myeloablative peripheral stem cell transplant; E MS MA HSCT− HLA-matched sibling myeloablative hematopoeitic stem cell transplant; F MU MA PSC− HLA-matched unrelated myeloablative hematopoieitc stem cell transplant; G autologous transplant after successful induction chemotherapy; N/A- not available; NR- no response; CR- complete response; PR- partial response.
- Figure S1. Comparison of SNP array analysis using bone marrow cells and CD3+ lymphocytes (JPG, 70.4 KB)
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Figure demonstrates SNP array analysis performed on bone marrow cells and normal CD3+ lymphocytes obtained from the same patient. The clonal lesions (red rectangles) are present in bone marrow and are not detected in CD3+ cells. Red dots correspond to individual SNP signal intensity values while blue lines represent an average value of SNP signal intensity (CN− copy number). Green vertical bars represent heterozygous SNP loci (Hetero SNP) while blue bars show areas of loss of heterozygosity (LOH). Four areas of UPD spanning chromosomes 4, 6, 11, 7 and one deletion on chromosome 7 are shown.
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