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Blood, Vol. 111, Issue 9, 4542-4550, May 1, 2008
Angiogenic endothelium shows lactadherin-dependent phagocytosis of aged erythrocytes and apoptotic cells
Blood Fens et al.
111: 4542
Supplemental materials for: Fens et al
Files in this Data Supplement:
- Figure S1. Images of endothelial cells (JPG, 28 KB)
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(A) SEM image of an endothelial cell in the process of phagocytosis of bound RGD-erythrocytes showing membrane ruffling after 1h incubation. Scale bar 2 µm. (B) TEM image of an endothelial cell, showing engulfment of an RGD-erythrocyte observed after 4 h incubation. Scale bar 1 µm.
- Figure S2. RGD-coupled erythrocytes (JPG, 96 KB)
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(A) Liver accumulation of RGD-coated erythrocytes, most probably taken up by Kupffer cells. 1 h post i.v. injection. Scale bar 200 µm. (B) Spleen accumulation of RGD-coupled erythrocytes in the red pulpa most likely by macrophages. 1 h post i.v. injection. Scale bar 200 µm. (C) Presence of occasional RGD-coupled erythrocytes in lung capillaries and vessels. 1 h post i.v. injection. Scale bar 50 µm.
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