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Blood, Vol. 111, Issue 3, 1013-1020, February 1, 2008
Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway
Blood Elias et al.
111: 1013
Supplemental materials for: Elias et al
Files in this Data Supplement:
- Figure S1. ATRA enhances FoxP3 and inhibits IL-17 expression independent of IL-2 (JPG, 92.4 KB)
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Peripheral CD4 cells from Il2−/−RAG2−/−TcR-transgenic mice were polyclonally stimulated for 3 days in media alone or with the addition of exogenous TGF -1, TGF-1 and IL-2 or Th17 conditions (TGF-1, IL-6, anti IFN- and anti IL-4). All stimulations were performed in the presence (lower panels) or absence (upper panels) of 1µM ATRA. IL-17 and FoxP3 expression were measured on fixed cells by intracellular staining.
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