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Blood, Vol. 111, Issue 8, 4403-4412, April 15, 2008
CCL8 is a potential molecular candidate for the diagnosis of graft-versus-host disease
Blood Hori et al.
111: 4403
Supplemental materials for: Hori et al
Files in this Data Supplement:
- Figure S1. Representative histology from GVHD mice on day 14 after BMT (JPG, 93.8 KB)
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Skin (a, b), liver (c, d), and small intestine (e, f) are shown. Mononuclear cell infiltrate into dermo-epidermal junction and thickening of the keratinocyte layer are present in (a). Injury to hair follicles (arrow) is visible in (b). Periportal mononuclear infiltrates with destruction of bile ducts are observed in (c). Hepatocytes undergoing necrosis (arrow) are present in (d). Apoptotic cells (arrow) are found in the small bowel crypts in (e). Dilatation and flattening of small intestinal villi is observed in (f). Original magnification is ×40 for a, ×100 for b, c, d and f, ×200 for e.
- Figure S2. Diagram of a classification tree for GVHD (JPG, 46.5 KB)
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Fifty GVHD plasma and 28 control plasma were used for the analysis. The peak at 8,972Da was chosen to establish the classification tree with 100% specificity and 100% sensitivity (A). In contrast, the 9,182Da peak set up a classification tree with lower discriminatory power (B). The mass value in the root nodes is followed by the intensity value or less.
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