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Blood, Vol. 111, Issue 4, 2007-2014, February 15, 2008
Inhibition of collagen-induced platelet aggregation by anopheline antiplatelet protein, a saliva protein from a malaria vector mosquito
Blood Yoshida et al.
111: 2007
Supplemental materials for: Yoshida et al
Files in this Data Supplement:
- Figure S1. Nucleotide and deduced amino acid sequences of the aapp cDNA (JPG, 193 KB)
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(A) The signal peptide sequence is underlined. The tandem repeat amino acid units (GEEGA and related amino acid sequences) are boxed. The predicted N-terminal sequence of AAPP at amino acid residues 22-31 (SDETTDQESS; shaded) exactly matches the previously determined N-terminal sequences of 10 major proteins in the salivary glands of A. stephensi.1 (B) Alignment of AAPP GE-rich region with human collagen type IV  -1 chain triple-helix region. An identical and similar amino acid residues are indicated as two and one asterisk, respectively. The nucleotide sequence of the aapp gene has been deposited in GenBank under accession number AB212871.
REFERENCES
1. Suwan N, Wilkinson MC, Crampton JM, Bates PA. Expression of D7 and D7-related proteins in the salivary glands of the human malaria mosquito Anopheles stephensi. Insect Mol Biol. 2002;11:223-232.
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