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Blood, Vol. 111, Issue 10, 5086-5092, May 15, 2008
Ki11502, a novel multitargeted receptor tyrosine kinase inhibitor, induces growth arrest and apoptosis of human leukemia cells in vitro and in vivo
Blood Nishioka et al.
111: 5086
Supplemental materials for: Nishioka et al
Files in this Data Supplement:
- Figure S1. Colony forming assay (JPG, 66.2 KB)
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CD34+ hematopoietic stem cells were isolated from healthy volunteers (n=3) by magnetic cell sorting utilizing CD34 MicroBeads (Miltenyi Biotec GmbH, Germany). CD34+ or freshly isolated AML cells (cases #1-3, Table 3) were resuspended in methylcellulose medium H4534 and were plated in 24 well plates in the presence or absence of Ki11502 (2 µM). The resulting colonies were counted 2 weeks later. All experiments were done in triplicate plates per experimental point.
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