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Blood, Vol. 112, Issue 3, 585-591, August 1, 2008
Maternal Par4 and platelets contribute to defective placenta formation in mouse embryos lacking thrombomodulin
Blood Sood et al.
112: 585
Supplemental materials for: Sood et al
Files in this Data Supplement:
- Figure S1. Phenotype of Thbd−/− embryos in Par4−/− mothers (JPG, 29.7 KB)
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All embryos were photographed at 9.5dpc. Thbd−/− embryos (A, bottom row) are invariably resorbed in a Par4+/+Thbd+/− mother. A wild type littermate (A, top row) is shown for comparison. The absence of Par4 in the mother partially rescued the developmental arrest of Thbd−/− embryos. At 9.5 dpc Thbd−/− embryos in a Par4−/− Thbd+/− mother (B) were of heterogenous size, several of them being smaller or severely retarded, and about half of them had beating hearts at the time of dissection. Scale bars represent 1 mm.
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