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Blood, Vol. 111, Issue 9, 4797-4808, May 1, 2008 This Article Abstract Full Text Services Email this article to a friend Alert me to new issues of the journal Rights and Permissions Citing Articles Citing Articles via CrossRef Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia Blood Tomasson et al. 111: 4797 Supplemental materials for: Tomasson et al Files in this Data Supplement: Table S1. Re-sequencing primers used for RTK and CTK genes (PDF, 109 KB) Table S2. Oligonucleotide primers used for pyrosequencing (PDF, 10.7 KB) Table S3. Prioritization of receptor tyrosine kinase (RTK) (A) and cytoplasmic tyrosine kinase (CTK) (B) genes by expression in AML cases (PDF, 71.1 KB) Table S4. Re-sequencing coverage of RTK and CTK genes (PDF, 17.6 KB) Figure S1. Sequence traces for NTRK1S677N and DDR1A803V somatic mutations (JPG, 108 KB) - Both sequence variants are seen reproducibly in forward and reverse reads from the bone marrow samples (tumor), but not in traces from skin DNA reactions (germline). Figure S2. Non-synonymous base changes identified by exonic re-sequencing of DNAs from 94 AML patients in validation (CALGB) set (JPG, 386 KB) - Patient Numbers are shown in the rows, and the names of sequenced genes are shown in the columns. Green color indicates that no non-synonymous sequence variants were identified in that sample. Red color identifies samples with non-synonymous variants; the predicted consequences of all sequence variants detected are listed. Yellow color indicates the presence of a homozygous sequence variant. White boxes indicate that no sequence was obtained. All somatic mutations were confirmed by automated resequencing and/or hand validation. This Article Abstract Full Text Services Email this article to a friend Alert me to new issues of the journal Rights and Permissions Citing Articles Citing Articles via CrossRef

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