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Blood, Vol. 111, Issue 10, 5093-5100, May 15, 2008 This Article Abstract Full Text Services Email this article to a friend Alert me to new issues of the journal Rights and Permissions Citing Articles Citing Articles via CrossRef The novel histone deacetylase inhibitor, LBH589, induces expression of DNA damage response genes and apoptosis in Ph– acute lymphoblastic leukemia cells Blood Scuto et al. 111: 5093 Supplemental materials for: Scuto et al Files in this Data Supplement: Figure S1. LBH589 inhibits proliferation of NALM-6 and SUP-B15 cells (JPG, 70.9 KB) - Pre-B Ph− ALL NALM-6 cells (A) and Ph+ SUP-B15 cells (B) were treated with indicated concentrations of LBH589 for 48 hours. Following this, the percentage of cell proliferation inhibition was determined by MTS assay. Values represented as graphs are the mean of 3 independent experiments plus the standard deviation. Figure S2. Differential sensitivity to LBH589 in cancer and normal cells (JPG, 61.5 KB) - Different human cancer cell lines, K562 (CML), HH (CTCL) and HCT116 (CRC) as well as human normal epithelial (HMEC and HRE), normal fibroblast (IMR90) and normal lymphocytes (PBMCs), were treated with LBH589 and apoptotic cell death was measured by caspase 3 and caspase 7 cleavage using flow cytometry. This Article Abstract Full Text Services Email this article to a friend Alert me to new issues of the journal Rights and Permissions Citing Articles Citing Articles via CrossRef

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