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Blood, Vol. 111, Issue 8, 4329-4337, April 15, 2008
High EVI1 levels predict adverse outcome in acute myeloid leukemia: prevalence of EVI1 overexpression and chromosome 3q26 abnormalities underestimated
Blood Lugthart et al.
111: 4329
Supplemental materials for: Lugthart et al
Files in this Data Supplement:
- Table S1. Oligonucleotide sequences of forward (fw) and reverse (rev) primers and probe used for real-time quantitative PCR and corresponding references (PDF, 40 KB)
- Table S2. Clinical characteristics of AML cohort A (n=272) and B (n=262) (PDF, 22.3 KB)
- Table S3. Univariable and multivariable analysis with the relative expression of EVI1 splice variants −1A, −1B, −1D and −3L as continuous variable (PDF, 30.5 KB)
- Table S4. Characteristics of AML patients with high EVI1 expression based on low versus high MDS1/EVI1 (ME) expression (PDF, 32.9 KB)
- Figure S1. Kaplan Meier analysis based on EVI1-1D expression in an independent cohort of AML patients (JPG, 99.5 KB)
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(A) overall survival (OS) and (B) event-free survival (EFS) according to splice variant EVI1-1D expression levels in an independent cohort of 272 AML patients are shown.
- Figure S2. Scatter plots of log2 relative expression from each EVI1 splice variant revealing high correlation between EVI1 splice variants (JPG, 163 KB)
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Spearman correlation coefficients (2-tailed, P<0.001) are depicted in each corresponding plot.
- Figure S3. FISH analysis of chromosome 3q26, 3q21 and 3qtel in AML patients with high EVI1 expression (JPG, 122 KB)
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The results of interphases and/or methaphases of patient (A) #18, (B) #29, (C) #1, (D-E) #5 and (F) a representative EVI1+ME+ AML patient are shown. The patient numbers correspond to Table 1.The BAC clones and labelling are shown per block. The location of the BAC clones are depicted in Figure 3.
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