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Blood, Vol. 112, Issue 2, 277-286, July 15, 2008
Common variable immunodeficiency disorders: division into distinct clinical phenotypes
Blood Chapel et al.
112: 277
Supplemental materials for: Chapel et al
Files in this Data Supplement:
- Figure S1. Flow diagram (JPG, 33.5 KB)
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- Figure S2. Serum Immunoglobulin isotypes at diagnosis (JPG, 52.9 KB)
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Patients are divided into four boxes depending on their presenting IgA level. Each box is subdivided by the IgM level into three columns, with those with the lowest IgM levels (≤0.1 g/l) in the first column; those with the highest IgM (>0.5 g/l) in the third column and those with IgM levels between (0.110.5 g/l) in the second column. Each column is divided into three, depending on the IgG level; those in the lower part with IgG ≤ 1.0 g/l; those with IgG > 3.0 ≤ 6.5 g/l at the top and those with IgG 1.1-3 g/l in the middle. The number of patients in each group is in each box and plotted on the y axis.
- Figure S3. Age at onset of symptoms for 389 patients across Europe (JPG, 86.3 KB)
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Number of patients for each age of onset is given on the y-axis. There was a wide range over a continuous curve, close to a Gaussian distribution Kurtosis was 2.7 compared with 3.0 for a normal distribution.
- Figure S4. Autoimmunity by centre (JPG, 75.8 KB)
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(A) Proportions of each cohort affected by each complication, by centre to show variability. Blue bars represent Freiburg; mauve bars Gothenberg; yellow bars Stockholm; green bars Oxford; purple bars Brno. (B) Crohns disease and polyclonal lymphocytic infiltrative diseases by centre: proportions of each cohort affected by each complication, by centre to show variability. Blue bars represent Freiburg; mauve bars Gothenberg; yellow bars Stockholm; green bars Oxford; purple bars Brno.
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